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Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model / 医学前沿
Frontiers of Medicine ; (4): 618-625, 2019.
Article em En | WPRIM | ID: wpr-771292
Biblioteca responsável: WPRO
ABSTRACT
This study aimed to compare clinical features between membranous nephropathy (MN) and nonmembranous nephropathy (non-MN), to explore the clinically differential diagnosis of these two types, and to establish a diagnostic model of MN. After renal biopsy was obtained, 798 patients were divided into two groups based on their examination results: primary MN group (n = 248) and non-MN group (n = 550). Their data were statistically analyzed. Logistic regression analysis indicated that anti-PLA2R antibodies, IgG, and Cr were independently correlated with MN, and these three parameters were then used to establish the MN diagnostic model. A receiver operating characteristic (ROC) curve confirmed that our diagnostic model could distinguish between patients with and without MN, and their corresponding sensitivity, specificity, and AUC were 79.9%, 89.4%, and 0.917, respectively. The cutoff value for this combination in MN diagnosis was 0.34. The established diagnostic model that combined multiple factors shows a potential for broad clinical applications in differentiating primary MN from other kidney diseases and provides reliable evidence supporting the feasibility of noninvasive diagnosis of kidney diseases.
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Texto completo: 1 Base de dados: WPRIM Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article