A Case of Premature Ovarian Failure Assosiated with Gonadal Dysgenesis / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
; : 138-141, 1999.
Article
em Ko
| WPRIM
| ID: wpr-77540
Biblioteca responsável:
WPRO
ABSTRACT
Prenature ovarian failure is a condition causing amenarrhea, hypoestrogenism, and elevated genadotropins in women younger than 40 years. A karyotype should be performed as part of basic laboratory evaluation for all patients with premature ovarian failure and prodromal premature ovarian failure. Development of a malignancy in a dysgenetic gonad is of major concern. The presence of a fragment of the Y chromosome is thought to be a key to the oncogenic potential of these gonads. The search for the testicular determining factor(TDF) has engendered much confusion about which part of the Y chromosome plays a role in malignancy. This was initially postulated to be the H- Y antigen. More recent data, however, localize the area near the centromere of the Y Chromosome, on the long arm(Yq). Malignant potential is clearly not linked to the testicular determining factor itself(SRY). This is a critical point in clinical medicine. Feilure to display SRY or a closely related sequence does not rule out the presence of the segment of the Y chromosome postulated to be associated with the development of malignancies. We have experienced a case of premature ovarian failure with chtomosomal abnormality involving Y chromosome fragment. So we report this case with a brief review of literatures.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Cromossomo Y
/
Medicina Clínica
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Centrômero
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Insuficiência Ovariana Primária
/
Cariótipo
/
Disgenesia Gonadal
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Gônadas
Limite:
Female
/
Humans
Idioma:
Ko
Ano de publicação:
1999
Tipo de documento:
Article