Effects of CeA lesions on the initiation and expression of sodium appetite in sodium-deficient rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 13-18, 2019.
Article
em Zh
| WPRIM
| ID: wpr-776567
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the effects of central nucleus of amygdala (CeA) lesion on the initiation and expression of sodium appetite in sodium-deficient rats.@*METHODS@#Three groups of SD rats (n=6 in each group) were treated with bilateral CeA lesion, sham lesion or no lesion. After the recovery, the rats were fed with low-sodium diets for 14 days to establish a sodium-deficient rat model. The double-bottle selection in single cage test was used to observe the intake of 0.3 mol/L NaCl and DW in 5 timepoint with 24 hours in sodium-deficient rats. Immunofluorescence staining of aldosterone-sensitive neurons in the nucleus tractus solitarii (NTS)was used to investigate the effect of CeA lesion or not on the activity of aldosterone-sensitive neurons in rats with or without sodium deficiency.@*RESULTS@#After fed with low-sodium diet for14 days, the volume and preference rate of 0.3 mol/L NaCl intake of the rats within 24 h were significantly increased compared with those before low-sodium diet (P<0.01). The intake volume and the preference rate of 0.3 mol/L NaCl in CeA lesion rats were significantly decreased than those in CeA sham lesion rats and normal rats in the sodium-deficient condition (P<0.01). The CeA lesion had no effects on the activity of aldosterone-sensitive neurons in NTS in rats with low-sodium diet.@*CONCLUSION@#Low-sodium diet induces an increase in the expression of sodium appetite in rats. CeA lesions inhibit the behavioral expression of sodium appetite in sodium-deficient rats but have no effects on the initiation of sodium appetite in rats with sodium-deficient rats.
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Base de dados:
WPRIM
Assunto principal:
Patologia
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Apetite
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Farmacologia
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Sódio
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Sódio na Dieta
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Ratos Sprague-Dawley
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Dieta Hipossódica
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Tonsila do Cerebelo
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Neurônios
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2019
Tipo de documento:
Article