Serine/arginine-rich splicing factors 2 (SRSF2) and SRSF4 expression patterns in Korean with colon cancer
Korean Journal of Clinical Oncology
; (2): 115-118, 2016.
Article
em Ko
| WPRIM
| ID: wpr-787988
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: Splicing factors play important roles in tumorigenesis. Serine/arginine-rich splicing factors 2 (SRSF2) and SRSF4 proteins, the members of SR family proteins, are dysregulated in various cancers. However, their protein expression levels and diagnostic values are unclear in colorectal cancer.METHODS: We quantified the protein levels of SRSF2, SRSF4, and previously known colon cancer markers (heterogeneous nuclear ribonucleoprotein A1 [HNRNPA1] and carcinoembryonic antigen [CEA]) in tumor compared with adjacent normal-looking areas (non-tumor) of the colon in Korean patients with colon cancer using immunoblot analysis.RESULTS: The protein levels of HNRNPA1 and CEA were remarkably increased in tumor compared to non-tumor tissue and up-regulated in all of the tumor samples. However, the protein levels of SRSF2 and SRSF4 in tumor tissue were reduced in contrast with those of non-tumor tissue.CONCLUSION: None of the SRSF proteins were significantly different between the low (≤II) and high (>II) stages.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Ribonucleoproteínas
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Neoplasias Colorretais
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Antígeno Carcinoembrionário
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Colo
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Neoplasias do Colo
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Carcinogênese
Limite:
Humans
Idioma:
Ko
Ano de publicação:
2016
Tipo de documento:
Article