Study on virulence related sites based on human enterovirus A71 genome / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 318-322, 2018.
Article
em Zh
| WPRIM
| ID: wpr-806195
Biblioteca responsável:
WPRO
ABSTRACT
Objective@#To explore the virulence related risk factors based on the enterovirus A71 (EV-A71) genome.@*Methods@#The pairwise distance of each section of gene between mild and fatal cases was analyzed. The ⅴ domain of 5′UTR from mild and fatal cases in this study were constructed. Amino acid sequences of EV-A71 were analyzed to find the potential virulence regions which were statistically different between fatal and mild cases.@*Results@#The two EV-A71 genome sequences in this study belonged to C4a genotype with the genomic homology of 96.2%-97.5%. The nucleotides in the ⅴ domains of the 5 ′UTR of EV-A71 from mild and fatal cases were the same. Each gene of EV-A71 from 31 mild cases and 30 fatal cases shared high homology. A total of four potential virulence sites (2 A R68 M、2C K41R、3 A T/V47 A and 3C I158 V) which were significantly different between mild cases and fatal cases were obtained.@*Conclusions@#The four sites in the unstructured protein coding region might be related with the virulence of EV-A71.
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Risk_factors_studies
Idioma:
Zh
Ano de publicação:
2018
Tipo de documento:
Article