Cytotoxicity and anti-inflammatory effects of root bark extracts of Acanthopanax henryi / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 121-125, 2014.
Article
em En
| WPRIM
| ID: wpr-812300
Biblioteca responsável:
WPRO
ABSTRACT
AIM@#To investigate the cytotoxicity, anti-inflammatory activity, and action mechanism of root bark extracts of Acanthopanax henryi.@*METHOD@#The hot methanol extract of the root bark of A. henryi was subjected to XAD-4 column chromatography eluting with a gradient of methanol in water. The cytotoxicity and anti-inflammatory effects of the MeOH fractions were evaluated on the inhibition on lipopolysaccharide (LPS)-induced nitric oxide, prostaglandin E2, interleukin-1β, and interleukin-6 production in RAW 264.7 macrophages.@*RESULTS@#The 80% MeOH fraction was a better inhibitor of LPS-induced NO, PGE2, IL-1β, and IL-6 production, and expression of inducible nitric oxide synthase (iNOS) at the protein levels in a concentration-dependent manner.@*CONCLUSION@#The 80% MeOH fraction of A. henryi root bark has significant anti-inflammatory activity. This provides a pharmacological basis for clinical application for the treatment of inflammation.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Extratos Vegetais
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Dinoprostona
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Lipopolissacarídeos
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Interleucina-6
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Raízes de Plantas
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Eleutherococcus
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Casca de Planta
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Usos Terapêuticos
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Relação Dose-Resposta a Droga
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article