Chemical constituents of Euphorbia tibetica and their biological activities / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 38-42, 2014.
Article
em En
| WPRIM
| ID: wpr-812311
Biblioteca responsável:
WPRO
ABSTRACT
AIM@#To investigate the chemical constituents and their biological activities of the aerial parts of Euphorbia tibetica.@*METHOD@#Compounds were isolated and purified by various chromatographic methods, and their structures were elucidated through the use of extensive spectroscopic techniques including 2D-NMR, the structures of compounds 5 and 6 were confirmed by single-crystal X-ray crystallography. Bioactivities of all the isolated compounds were evaluated by the MTT method on A549 and anti-angiogenesis assay.@*RESULTS@#One new compound, methyl 4-epi-shikimate-3-O-gallate (1), together with twenty-three known constituents (2-24) were isolated from the aerial parts of E. tibetica.@*CONCLUSION@#Compound 1 is new, and the other compounds were isolated from this plant for the first time. Compounds 5-7, 9, 11, 17, 18 and 20 exhibited inhibitory effects on the growth of human lung cancer cell A549 and compounds 5, 7, 12, 13, 17 and 19 showed anti-angiogenic effects in a zebrafish model.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Peixe-Zebra
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Medicamentos de Ervas Chinesas
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Estrutura Molecular
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Linhagem Celular
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Química
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Inibidores da Angiogênese
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Euphorbia
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Proliferação de Células
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Inibidores do Crescimento
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article