Comparison of Virulence Factor Expression between Blood Isolates of Candida albicans and Commensal Strain Isolated from Healthy Volunteers
Journal of the Korean Society for Microbiology
; : 429-434, 1997.
Article
em Ko
| WPRIM
| ID: wpr-81353
Biblioteca responsável:
WPRO
ABSTRACT
In the present study, we investigated the differences in the levels of expression of virulence factors between blood isolates of Candida albicans and commensal strain isolated from the oral cavities of health volunteers, and correlations between virulence factors. Blood isolates of 33 and commenal isolates of 71 were characterized by putative virulence factors such as proteinase production (PROT), an ability to adhere to epithelial cells (ADH), cell surface hydrophobicity (CSH), phospholipase production (PLASE), and hyphal transition (GERM). In PROT, ADH, CSH, and PLASE, the means of expression of blood isolates were higher compared with those of commensal isolates, however statistical significance was only shown in CSH (p=0.036). On the contrary, mean expression of GERM of blood isolates was lower than that of commensal isolates. Of relationships between virulence factors, although a negative correlation of PROT with CSH was obtained, the correlation was relatively low (r=-0.316, p=0.001). These results suggest that higher expression of CSH is a more distinguishing character in virulent blood isolates of C. albicans and that the expression of virulence factors are independent.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fosfolipases
/
Virulência
/
Voluntários
/
Candida
/
Candida albicans
/
Fatores de Virulência
/
Células Epiteliais
/
Interações Hidrofóbicas e Hidrofílicas
/
Voluntários Saudáveis
Idioma:
Ko
Ano de publicação:
1997
Tipo de documento:
Article