(1)H-magnetic resonance spectroscopy on bilateral thalamus of patients with secondarily generalized tonic-clonic seizures / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 1147-1151, 2012.
Article
em Zh
| WPRIM
| ID: wpr-814721
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To examine the changes of metabolites in the bilateral thalamus of patients with secondarily generalized tonic-clonic seizure (SGTCS) and to explore the mechanism of SGTCS.@*METHODS@#Thirty patients with SGTCS (epilepsy group) and 30 matched healthy controls (control group) were examined by 1H-magnetic resonance spectroscopy (1H-MRS). The levels of N-acetyl aspartate (NAA), choline-containing compounds (Cho), creatine phosphocreatine (Cr-PCr), and myo-inositol (mI) of the bilateral thalamus were measured in both the epilepsy group and the control group. The ratios of NAA/Cr-PCr, NAA/(Cr-PCr+Cho), Cho/Cr-PCr and mI/Cr-PCr were compared and analyzed in the 2 groups.@*RESULTS@#The ratios of NAA/Cr-PCr, and NAA/(Cr-PCr+Cho)(1.7074 ± 0.2214; 0.9333 ± 0.2173) in the left thalamus in the epilepsy group were significantly lower than those in the control group(1.8834 ±0.2093; 1.1243 ±0.2447)(P0.05).@*CONCLUSION@#There is neuronal dysfunction in the bilateral thalamus in the epilepsy group. Abnormal changes of the bilateral thalamus are involved in the mechanism of SGTCS.
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Base de dados:
WPRIM
Assunto principal:
Fisiologia
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Tálamo
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Química Encefálica
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Espectroscopia de Ressonância Magnética
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Estudos de Casos e Controles
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Colina
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Epilepsia Generalizada
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Epilepsia Tônico-Clônica
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Ácido Aspártico
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Metabolismo Energético
Tipo de estudo:
Observational_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
Zh
Ano de publicação:
2012
Tipo de documento:
Article