Clinical characteristics related to onset age of wheeze in school-age children and adolescents with asthma
Allergy, Asthma & Respiratory Disease
; : 326-333, 2015.
Article
em Ko
| WPRIM
| ID: wpr-81730
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: We aimed to investigate the clinical characteristics and their relationship with the onset age of wheeze in school-age children and adolescents with asthma. METHODS: Three hundred twenty-six patients, aged 6 to 19 years, diagnosed with asthma at 6 hospitals from Seoul, Gyeonggi, Daegu, and Busan were enrolled. They were categorized into 3 groups by the onset age of wheeze: group A, early onset (age or =6 years). Clinical characteristics including atopic sensitization, family history, combined allergic diseases, severity of asthma, and influence of asthma on daily life were examined. A history of hospitalization for early lower respiratory infection (LRI) and environmental tobacco smoking were studied and lung function tests were also performed. RESULTS: There was no difference in demographics, prevalence of atopy, combined allergic diseases, and family history of allergy between 3 groups. A history of sever LRI in early life was more common in groups A and B compared with group C. Sensitization to Dermatophagoides pteronyssinus was more prevalent in groups A and B than in group C. Forced expiratory flow between 25% to 75% (FEF(25%-75%)) was lower in groups A and B than in group C, and methacholine PC20 (provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second) was lowest in group B. Significantly lower FEF(25%-75%) and methacholine PC20 were observed in the patients who had been hospitalized with LRI in early life. CONCLUSION: Our study shows significant difference in lung function and atopic sensitization in relation to the onset age of wheeze in school-age children and adolescents with asthma, and suggests that early LRI might contribute to the development of asthma in early life.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Testes de Função Respiratória
/
Asma
/
Fumar
/
Demografia
/
Volume Expiratório Forçado
/
Prevalência
/
Cloreto de Metacolina
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Idade de Início
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Dermatophagoides pteronyssinus
/
Seul
Tipo de estudo:
Prevalence_studies
Limite:
Adolescent
/
Child
/
Humans
País como assunto:
Asia
Idioma:
Ko
Ano de publicação:
2015
Tipo de documento:
Article