Reasearch updates of microRNAs in IgA nephropathy / 医学研究生学报

ABSTRACT

IgA nephropathy (IgAN) is the most common primary glomerulonephritis and is also one of the main causes of the end-stage renal disease. The pathogenesis of IgAN has not yet fully clarified and the clinical manifestations are diverse. At present, there are no specific molecular biomarkers and therapeutic drugs for IgAN, which leads the prognosis quite different among patients. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the post-transcriptional level and involved in many pivot physiological and pathological processes. Numerous studies have demonstrated that miRNAs were tissue or organ specific and abundantly and stably existed in the peripheral blood as well as human urine. Thus, deregulated miRNAs have the potential as novel candidate biomarkers for many diseases. Recent studies revealed that miRNAs also play important roles in the pathophysiology of renal diseases. The aim of the present review is to highlight recent research updates for the clinical value of miRNAs and their roles participated in the molecular mechanism of IgAN, which may provide new ideas for the diagnosis and treatment of IgAN.