Important roles of growth hormone-releasing peptide in bone growth and development / 中国组织工程研究

ABSTRACT

BACKGROUND: Growth hormone-releasing peptide (Ghrelin) can promote the secretion of growth hormones, regulate the balance of energy metabolism and have some unknown pharmacological properties, which are closely related to the body’s metabolic state. OBJECTIVE: To review the regulatory effect of Ghrelin on skeletal cell function and its integration in bone metabolism and energy metabolism, in order to clarify the important role of Ghrelin in skeletal development. METHODS: PubMed database was searched for relevant literature published from January 1993 to January 2017. Search words were “ghrelin, bone metabolism, leptin, osteoblast, osteoclast, castric resection, cartilage cells.” After removal of repetitive studies and inconsistent literature, 74 eligible articles were included in final analysis. RESULTS AND CONCLUSION: The remodeling of the body’s skeletal system is a highly energy-consuming process. Correspondingly, the growth and development of the skeleton involves the energy metabolism of peripheral and central nervous systems, including the sympathetic nervous system and hormones such as leptin. Recent studies abroad have shown that Ghrelin can regulate the differentiation and function of osteoblasts, induce the proliferation and differentiation of bone marrow stem cells, and regulate the state of Ghrelin-insulin axis in different ways. Ghrelin can also regulate bone metabolism and energy metabolism through interaction with leptin, thus affecting the skeletal growth.