Clinical study on Lp-PLA2 levels in different types of cognitive impairment / 中国脑血管病杂志
Chinese Journal of Cerebrovascular Diseases
; (12): 243-247, 2011.
Article
em Zh
| WPRIM
| ID: wpr-856097
Biblioteca responsável:
WPRO
ABSTRACT
Objective: To evaluate the expression levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) in various types of cognitive impairment. Methods: A total of 212 patients were included in the study. They were divided into mild cognitive impairment (MCI) (n = 46), Alzheimers disease (AD) (n = 58), vascular dementia (VD) (n = 84), and control (n = 24) groups after being screened and evaluated. The concentrations of plasma Lp-PLA2 of patients in each group were measured and compared. The correlation between the Lp-PLA2 level and dementia was analyzed through Cox proportional hazards model. Results: Circled digit oneThe Lp-PLA2 levels in the MCI, AD and VD groups were 45 ± 4 μg/L, 83 ± 15 μg/L, and 112 ± 22 μg/L, respectively, and they were higher than 34 ± 3 μg/L in the control group. The difference was statistically significant (P < 0.05). Circled digit twoThe Lp-PLA2 level was 93 ± 8 μg/L in men, and it was higher than 73 ± 13 μg/L in women in the AD group. The difference was statistically significant (P < 0.05). The Lp-PLA2 level in men was 127 ± 21 μg/L, and it was higher than 97 ± 10 μg/L in women in the VD group. The difference was statistically significant (P < 0.05). Circled digit threeThe Cox proportional hazards model showed that the Lp-PLA2 level was correlated with the high risk of dementia. The correlation of VD was the highest, then AD, and MCI was the lowest. Conclusion: High level of Lp-PLA2 has correlation with mild cognitive impairment, and has gender differences in patients with vascular dementia and Alzheimer's disease, it may be contributive to early diagnosis of cognitive impairment.
Texto completo:
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Base de dados:
WPRIM
Tipo de estudo:
Screening_studies
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article