Acute lung injury induced by inhalable microparticles in rats / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the safety of inhalable microparticles in rats. METHODS: The safety of the microparticles was assessed by lung histology and analysis of the components in bronchoalveolar lavage fluid. RESULTS: The microparticles could induce acute lung injury in rats after inhalation, which showed dose dependency. Compared with the normal group, the concentrations of biochemical indicators in bronchoalveolar lavage fluid were increased, and pathological changes of lung tissues were observed after intrapulmonary delivery of the microparticles. CONCLUSION: Inhalable microparticles can induce acute lung injury in rats. More work should be done to establish systemic assessment for this drug delivery system. Copyright 2012 by the Chinese Pharmaceutical Association.