Research progress on protective effect of liver ischemia-reperfusion injury after liver transplantation / 国际外科学杂志
International Journal of Surgery
; (12): 212-216, 2020.
Article
em Zh
| WPRIM
| ID: wpr-863294
Biblioteca responsável:
WPRO
ABSTRACT
Hepatic ischemia-reperfusion injury is the most common complication after liver transplantation. Oxidative stress, autophagy, and inflammatory response caused by excessive reactive oxygen species production are significant steps that cause liver ischemia-reperfusion injury. What′s more, nuclear factor erythroid 2-related factor 2 is considered to be a major regulator of the antioxidant response, the PI3K-Akt-mTOR signaling pathway is considered to be an important pathway of autophagy, and the HMGB1-TLR4-NF-κB signaling pathway is considered to be a key signaling pathway which leads to inflammation. Based on the above signaling pathways and regulatory factor, this article shows that the antioxidant, anti-inflammatory and autophagy regulation effects of genes, molecules and drugs on hepatic ischemia-reperfusion cells, to explore the protective effects on hepatic ischemia-reperfusion cells.
Texto completo:
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Base de dados:
WPRIM
Idioma:
Zh
Ano de publicação:
2020
Tipo de documento:
Article