Inhibition of Murine Allergic Response by Monoclonal Interleukin-4 Receptor Antibody
Journal of Rhinology
; : 149-153, 2000.
Article
em En
| WPRIM
| ID: wpr-87954
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: Several strategies were used to control the IgE production by interfering the functional activities of IL-4. However, most of them revealed limited effects to reduction of allergic response. This study was aimed to investigate the effects of interleukin-4 receptor (IL-4R) antibody on allergic response in animal model of allergic rhinitis. MATERIALS AND METHODS: Male BALB/C mice were sensitized with intraperitoneal injection of ovalbumin (OVA). IL-4R antibody was injected intravenously before intranasal challenge of OVA with ultrasonic nebulizer. Allergic symptoms, a number of eosinophils in nasal mucosa and serum level of OVA-specific IgE were evaluated. RESULTS: In IL-4R antibody treated mice, allergic symptom score were decreased (53.5%) than in control mice. The number of eosinophils in nasal mucosa were also reduced (47.4%). However, serum level of OVA-specific IgE were not obviously reduced (14.3%). CONCLUSION: These results suggested that IL-4R antibody has a potential effect for the treatment of allergic rhinitis in vivo.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Óvulo
/
Ultrassom
/
Nebulizadores e Vaporizadores
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Imunoglobulina E
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Ovalbumina
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Rinite
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Interleucina-4
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Modelos Animais
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Eosinófilos
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Injeções Intraperitoneais
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
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Male
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article