Protective effect of transplantation of human oligodendrocyte precursor cells in a rat model of white matter injury / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 410-415, 2021.
Article
em Zh
| WPRIM
| ID: wpr-879868
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To study the effect of human oligodendrocyte precursor cell (hOPC) transplantation in the treatment of white matter injury (WMI).@*METHODS@#Neonatal rats were randomly divided into a sham-operation group, a model group, and a transplantation group (@*RESULTS@#The place navigation test using the Morris water maze showed that the model group had a significantly longer escape latency than the sham-operation group, and compared with the model group, the transplantation group had a significant reduction in escape latency (@*CONCLUSIONS@#Intrathecal hOPC transplantation may alleviate neurological injury and promote remyelination in a rat model of WMI.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Oligodendroglia
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Substância Branca
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Células Precursoras de Oligodendrócitos
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Animais Recém-Nascidos
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Bainha de Mielina
Limite:
Animals
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Humans
Idioma:
Zh
Ano de publicação:
2021
Tipo de documento:
Article