Cancer Chemoprevention by Ginseng in Mouse Liver and Other Organs
Journal of Korean Medical Science
; : S66-S69, 2001.
Article
em En
| WPRIM
| ID: wpr-90521
Biblioteca responsável:
WPRO
ABSTRACT
Oral administration of red ginseng extracts (1% in diet for 40 weeks) resulted in the significant suppression of spontaneous liver tumor formation in C3H/He male mice. Average number of tumors per mouse in control group was 1.06, while that in red ginseng extracts-treated group was 0.33 (p<0.05). Incidence of liver tumor development was also lower in red ginseng extracts-treated group, although the difference from control group was not statistically significant. Anti-carcinogenic activity of white ginseng extracts, besides red ginseng extracts, was also investigated. In the present study, the administration of white ginseng extracts was proven to suppress tumor promoter-induced phenomena in vitro and in vivo. It is of interest that oral administration of the extracts of Ren-Shen-Yang- Rong-Tang, a white ginseng-containing Chinese medicinal prescription, resulted in the suppression of skin tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated CD-1 mice. These results suggest the usefulness of ginseng in the field of cancer prevention.
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Base de dados:
WPRIM
Assunto principal:
Neoplasias Cutâneas
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Extratos Vegetais
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Anticarcinógenos
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Raízes de Plantas
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Panax
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Neoplasias Hepáticas Experimentais
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Animais
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Camundongos Endogâmicos C3H
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article