Advances in self-assembled peptide hydrogels for bone regeneration / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 356-364, 2022.
Article
em Zh
| WPRIM
| ID: wpr-929475
Biblioteca responsável:
WPRO
ABSTRACT
@#The development of osteoinductive bone-filling biomaterials for bone regeneration is of great significance.Self-assembled peptide hydrogels with high biomimetic extracellular matrix structure, low immunogenicity, easy synthesis and modification, and flexible loading capacity provide a highly efficient therapeutic platform for bone tissue repair.Herein, we discuss the design principles of self-assembled peptide hydrogels, report the structural characteristics and assembly mechanisms of self-assembled peptides, and highlight recent advances in self-assembled peptide hydrogels for bone regeneration, including delivery to cells , bone morphogenetic proteins, active factors and small molecular substances.Finally, the bottleneck and development direction of self-assembled peptide hydrogels are pointed out, aiming to provide guidance for the construction of hydrogel delivery systems with high osteogenic properties.
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Base de dados:
WPRIM
Tipo de estudo:
Guideline
Idioma:
Zh
Ano de publicação:
2022
Tipo de documento:
Article