Research progress of mTOR in digestive system neoplasms / 中国医师杂志

ABSTRACT

Mammalian target of rapamycin (mTOR) is involved in a variety of cellular signaling pathways, which is related to cell growth, proliferation, autophagy, apoptosis and cell cycle progression.mTOR signaling pathway is usually activated in tumors and is closely related to the occurrence, progression and metabolism of tumors.Therefore, mTOR signaling pathway is a hot spot in anti-tumor therapy research.In recent years, with the research of the mechanism of mTOR signaling pathway in digestive system tumors and the exploration of inhibitors, new ideas have been provided for clinical diagnosis and treatment, prognosis assessment and targeted drug development.