Research progress of epigenetic regulation in the pathogenesis of aluminum exposure / 中华预防医学杂志
Chinese Journal of Preventive Medicine
; (12): 240-244, 2022.
Article
em Zh
| WPRIM
| ID: wpr-935276
Biblioteca responsável:
WPRO
ABSTRACT
Aluminum is one of the most abundant elements on earth. Aluminum compounds are widely used in food additives, antacids, cooking utensils and so on. Human exposure to aluminum is mainly through diet and drinking water, while excessive intake of aluminum can accumulate in tissues and cause toxic reactions. In the central nervous system, aluminum exposure is closely related to a series of nervous system diseases such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Epigenetic modification refers to the regulation of gene expression without changing the DNA sequence, and its regulatory disorders can lead to abnormalities and diseases of the central nervous system. This paper describes the regulation of epigenetics and its components, including DNA methylation, histone modification and non-coding RNA, in aluminum-induced neurotoxicity, in order to provide insights into the epigenetic mechanism of aluminum-induced neurotoxicity.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Metilação de DNA
/
Culinária
/
Epigênese Genética
/
Alumínio
/
Doença de Alzheimer
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2022
Tipo de documento:
Article