Natural Course of Crohn's Disease and Novel Treatment Drugs / 대한내과학회지
Korean Journal of Medicine
; : 578-585, 2013.
Article
em Ko
| WPRIM
| ID: wpr-95749
Biblioteca responsável:
WPRO
ABSTRACT
Crohn's disease is a chronic recurrent inflammatory disease, mainly affecting the gastrointestinal tract. The pathogenesis of inflammatory bowel disease is believed to be caused by the complex interplay of many factors including host genetic susceptibility, the external environment such as infectious agents or the commensal enteric flora, and the immune system dysfunction. Advances in the understanding of the pathophysiology of inflammatory bowel disease have resulted in the development of multiple biological agents that all represent an alternative to the use of current therapies in patients with refractory Crohn's disease. Moreover, these biologic agents are expected to change the natural course of inflammatory bowel disease. Among them, anti-tumor necrosis factor (TNF)-alpha agent is the first developed drug, and it dramatically improved the IBD management. However, more than one-third of the patients do not respond to the drugs due to antibody formation and loss of response. To increase treatment efficacy, enormous efforts have been made to develop novel anti-cytokines which can be an alternative to anti-TNF-alpha agents. They are anti-CD4+ T cell cytokines including interleukin (IL)-12/23, IL-17A, and IFN-gamma blockers, selective anti-adhesion molecules, anti-inflammatory cytokine IL-10, and immune stimulators. This paper reviews the natural history of Crohn's disease, natural course modifiers, and the efficacy and safety of biologic agents other than anti-TNF alpha agents.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Doenças Inflamatórias Intestinais
/
Doença de Crohn
/
Citocinas
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Interleucinas
/
Resultado do Tratamento
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Interleucina-10
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História Natural
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Predisposição Genética para Doença
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Interleucina-17
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Trato Gastrointestinal
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Ko
Ano de publicação:
2013
Tipo de documento:
Article