A new macrocyclic flavonoid from Onychium japonicum / 药学学报
Acta Pharmaceutica Sinica
; (12): 423-428, 2023.
Article
em Zh
| WPRIM
| ID: wpr-965715
Biblioteca responsável:
WPRO
ABSTRACT
Seven compounds were isolated from Onychium japonicum by macroporous resin, silica gel, ODS, Sephadex LH-20 column chromatography and semi-preparative HPLC. Their structures were identified by NMR, MS and other spectroscopic methods as onychone A (1), quercetin (2), quercetin-3-O-α-L-rhamnoside (3), kaempferol-7-O-β-D-glucopyranoside (4), kaempferol-3-O-α-L-rhamnopyranoside (5), (-)-prunin (6), and norathyriol (7). Compound 1 is a novel macrocyclic flavonoid, and all the others are reported from this plant for the first time. In vitro cytotoxic activities of compounds 1-7 were evaluated by MTS testing with five cancer cell lines. Compound 7 exhibited weak cytotoxicity against tumor cell lines A549, SMMC-7721, and SW480.
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Base de dados:
WPRIM
Idioma:
Zh
Ano de publicação:
2023
Tipo de documento:
Article