Photodynamic Therapy for Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
Journal of the Korean Ophthalmological Society
; : 789-798, 2007.
Article
em Ko
| WPRIM
| ID: wpr-9671
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
To investigate the effects of repeated photodynamic therapy (PDT) for subfoveal choroidal neovascularization secondary to age-related macular degeneration (AMD) in Korean patients.METHODS:
Clinical data of patients who were treated with repeated (3 times or more) PDT for subfoveal choroidal neovascularization secondary to AMD and followed up for more than 6 months were collected from 17 hospitals around the country. Visual outcomes at 12 and 24 months, follow-up were compared between subtypes of choroidal neovascularization. The factors related to final visual prognosis and PDT-related adverse effects were evaluated.RESULTS:
244 patients (244 eyes) were recruited (male 60%, age 67.7+/-9.1 years). The portion of patients with predominantly classic, minimally classic, and occult without classic choroidal neovascularization was 57%, 13%, and 24%, respectively and that of patients with visual improvements or less than moderate visual loss at 24 months follow-up were 28%, 38%, 30% and 47%, 56%, and 65%, respectively. Baseline visual acuity and age were significantly related to the final visual prognosis (p<0.05). PDT-related adverse events developed in 15 (6.1%) patients, but most were mild and transient.CONCLUSIONS:
Repeated PDT for subfoveal choroidal neovascularization secondary to AMD has effects comparable to those of previous prospective, controlled trials without any significant safety concerns in Korea.Palavras-chave
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Fotoquimioterapia
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Prognóstico
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Acuidade Visual
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Seguimentos
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Corioide
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Neovascularização de Coroide
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Coreia (Geográfico)
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Degeneração Macular
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
País como assunto:
Asia
Idioma:
Ko
Ano de publicação:
2007
Tipo de documento:
Article