A review of progress in B cell receptor (BCR) antigen specificity / 细胞与分子免疫学杂志
Chinese Journal of Cellular and Molecular Immunology
; (12): 663-670, 2023.
Article
em Zh
| WPRIM
| ID: wpr-981914
Biblioteca responsável:
WPRO
ABSTRACT
B cell receptor (BCR) is a key molecule involved in B cell specific recognition and the binding of antigens to produce adaptive humoral immune response. Gene rearrangement and high frequency mutation during B cell differentiation are the main mechanisms of BCR diversification. The enormous diversity and unique molecular structure of BCR determine the diversity and specificity of antigen recognition, shaping complex B cell repertoire with extensive collections of antigen specificities. Therefore, BCR antigen-specific information is vital to understanding the adaptive immune characteristics of different diseases. Our ability to connect BCR repertoire and antigen specificity has been enhanced with the development of B cell related research technologies, such as single cell sorting techniques, high-throughput sequencing (HTS), linking B cell receptor to antigen specificity through sequencing (LIBRA-seq). It could help researchers to better understand humoral immune responses, identify disease pathogenesis, monitor disease progression, design vaccines, and develop therapeutic antibodies and drugs. We summarizes recent studies on antigen-specific BCR of infections, vaccinations, autoimmune diseases and cancer. By analyzing autoantibody sequences of SLE as a case, the identification of autoantigens has become potentially possible due to this characterization.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Linfócitos B
/
Ativação Linfocitária
/
Receptores de Antígenos de Linfócitos B
/
Sequenciamento de Nucleotídeos em Larga Escala
Idioma:
Zh
Ano de publicação:
2023
Tipo de documento:
Article