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Dev Comp Immunol ; 122: 104077, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-33905781

RESUMO

As an invertebrate, the compound ascidian Botryllus schlosseri faces nonself only with innate immunity. In this species, we already identified the key components of the lectin and alternative complement activation pathways. In the present work, by mining the transcriptome, we identified a single transcript codifying for a protein, member of the C1q-domain-containing protein family, with a signal peptide followed by two globular C1q (gC1q) domains. It shares a similar domain organisation with C1q/TNF-related proteins 4, the only vertebrate protein family with two gC1q domains. Our gC1q domain-containing protein, called BsC1qDC, is actively transcribed by immunocytes. The transcription is modulated during the Botryllus blastogenetic cycle and is upregulated following the injection of Bacillus clausii cells in the circulation. Furthermore, the injection of bsc1qdc iRNA in the vasculature results in decreased transcription of the gene and a significant impairment of phagocytosis and degranulation, suggesting the involvement of this molecule in immune responses.


Assuntos
Complemento C1q/imunologia , Imunidade Inata/imunologia , Opsonização/imunologia , Urocordados/imunologia , Sequência de Aminoácidos , Animais , Bacillus clausii/imunologia , Degranulação Celular/imunologia , Complemento C1q/genética , Hemócitos/metabolismo , Fagocitose/imunologia , Domínios Proteicos , Interferência de RNA , RNA Interferente Pequeno/genética , Transcriptoma/genética
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