Detalhe da pesquisa
1.
Synthesis and evaluation of novel N1-acylated 5-(4-pyridinyl)indazole derivatives as potent and selective haspin inhibitors.
Bioorg Chem
; 145: 107235, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38447464
2.
N1-Benzoylated 5-(4-pyridinyl)indazole-based kinase inhibitors: Attaining haspin and Clk4 selectivity via modulation of the benzoyl substituents.
Arch Pharm (Weinheim)
; 357(6): e2400020, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38478964
3.
Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents.
Arch Pharm (Weinheim)
; 357(4): e2300656, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38304944
4.
An overview of cdc2-like kinase 1 (Clk1) inhibitors and their therapeutic indications.
Med Res Rev
; 43(2): 343-398, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36262046
5.
Design, synthesis, and metabolite identification of Tamoxifen esterase-activatable prodrugs.
Bioorg Chem
; 131: 106303, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36455483
6.
Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer's disease.
J Enzyme Inhib Med Chem
; 38(1): 2175821, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36789662
7.
Novel 9-Benzylaminoacridine Derivatives as Dual Inhibitors of Phosphodiesterase 5 and Topoisomerase II for the Treatment of Colon Cancer.
Molecules
; 28(2)2023 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36677898
8.
Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part.
Bioorg Med Chem Lett
; 59: 128531, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35007723
9.
From EGFR kinase inhibitors to anti-inflammatory drugs: Optimization and biological evaluation of (4-(phenylamino)quinazolinyl)-phenylthiourea derivatives as novel NF-κB inhibitors.
Bioorg Chem
; 127: 105977, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35779404
10.
Development of fluorinated and methoxylated benzothiazole derivatives as highly potent and selective cannabinoid CB2 receptor ligands.
Bioorg Chem
; 114: 105191, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34375194
11.
Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Optimization of the 2,4-substituents.
Bioorg Chem
; 117: 105422, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34700110
12.
Novel thiazolidine derivatives as potent selective pro-apoptotic agents.
Bioorg Chem
; 114: 105143, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34328854
13.
Manipulating Estrogenic/Anti-Estrogenic Activity of Triphenylethylenes towards Development of Novel Anti-Neoplastic SERMs.
Int J Mol Sci
; 22(22)2021 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34830456
14.
5-Methoxybenzothiophene-2-Carboxamides as Inhibitors of Clk1/4: Optimization of Selectivity and Cellular Potency.
Molecules
; 26(4)2021 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33668683
15.
Synthesis of novel 1,2-diarylpyrazolidin-3-one-based compounds and their evaluation as broad spectrum antibacterial agents.
Bioorg Chem
; 99: 103759, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32220665
16.
Symmetric benzidine derivatives as anti-HCV agents: Insight into the nature, stereochemistry of the capping amino acid and the size of the terminal capping carbamates.
Bioorg Chem
; 102: 104089, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32717691
17.
Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors.
Bioorg Chem
; 104: 104322, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33142429
18.
Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors.
Bioorg Chem
; 98: 103742, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32199305
19.
Expanding the chemical space of anti-HCV NS5A inhibitors by stereochemical exchange and peptidomimetic approaches.
Arch Pharm (Weinheim)
; 351(7): e1800017, 2018 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-29799645
20.
Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors.
Arch Pharm (Weinheim)
; 351(5): e1800018, 2018 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-29656464