Quantum Effects in a Mechanically Modulated Single-Photon Emitter.

Recent observation of quantum emitters in monolayers of hexagonal boron nitride (h-BN) has provided a novel platform for optomechanical experiments where the single-photon emitters can couple to the motion of a freely suspended h-BN membrane. Here, we propose a scheme where the electronic degree of freedom (d.o.f.) of an embedded color center is coupled to the motion of the hosting h-BN resonator via dispersive forces. We show that the coupling of membrane vibrations to the electronic d.o.f. of the emitter can reach the strong regime. By suitable driving of a three-level Λ-system composed of two spin d.o.f. in the electronic ground state as well as an isolated excited state of the emitter, a multiple electromagnetically induced transparency spectrum becomes available. The experimental feasibility of the efficient vibrational ground-state cooling of the membrane via quantum interference effects in the two-color drive scheme is numerically confirmed. More interestingly, the emission spectrum of the defect exhibits a frequency comb with frequency spacings as small as the fundamental vibrational mode, which finds applications in high-precision spectroscopy.

Spin-Mechanical Scheme with Color Centers in Hexagonal Boron Nitride Membranes.

Recently observed quantum emitters in hexagonal boron nitride (hBN) membranes have a potential for achieving high accessibility and controllability thanks to the lower spatial dimension. Moreover, these objects naturally have a high sensitivity to vibrations of the hosting membrane due to its low mass density and high elasticity modulus. Here, we propose and analyze a spin-mechanical system based on color centers in a suspended hBN mechanical resonator. Through group theoretical analyses and ab initio calculation of the electronic and spin properties of such a system, we identify a spin doublet ground state and demonstrate that a spin-motion interaction can be engineered, which enables ground-state cooling of the mechanical resonator. We also present a toolbox for initialization, rotation, and readout of the defect spin qubit. As a result, the proposed setup presents the possibility for studying a wide range of physics. To illustrate its assets, we show that a fast and noise-resilient preparation of a multicomponent cat state and a squeezed state of the mechanical resonator is possible; the latter is achieved by realizing the extremely detuned, ultrastrong coupling regime of the Rabi model, where a phonon superradiant phase transition is expected to occur.

Parametric Oscillation, Frequency Mixing, and Injection Locking of Strongly Coupled Nanomechanical Resonator Modes.

We study locking phenomena of two strongly coupled, high quality factor nanomechanical resonator modes to a common parametric drive at a single drive frequency in different parametric driving regimes. By controlled dielectric gradient forces we tune the resonance frequencies of the flexural in-plane and out-of-plane oscillation of the high stress silicon nitride string through their mutual avoided crossing. For the case of the strong common parametric drive signal-idler generation via nondegenerate parametric two-mode oscillation is observed. Broadband frequency tuning of the very narrow linewidth signal and idler resonances is demonstrated. When the resonance frequencies of the signal and idler get closer to each other, partial injection locking, injection pulling, and complete injection locking to half of the drive frequency occurs depending on the pump strength. Furthermore, satellite resonances, symmetrically offset from the signal and idler by their beat note, are observed, which can be attributed to degenerate four-wave mixing in the highly nonlinear mechanical oscillations.

Quantum state engineering with circuit electromechanical three-body interactions.

We propose a hybrid system with quantum mechanical three-body interactions between photons, phonons, and qubit excitations. These interactions take place in a circuit quantum electrodynamical architecture with a superconducting microwave resonator coupled to a transmon qubit whose shunt capacitance is free to mechanically oscillate. We show that this system design features a three-mode polariton-mechanical mode and a nonlinear transmon-mechanical mode interaction in the strong coupling regime. Together with the strong resonator-transmon interaction, these properties provide intriguing opportunities for manipulations of this hybrid quantum system. We show, in particular, the feasibility of cooling the mechanical motion down to its ground state and preparing various nonclassical states including mechanical Fock and cat states and hybrid tripartite entangled states.

Common carotid artery intima-media thickness and atherosclerotic plaques in carotid bulb in patients with chronic kidney disease on hemodialysis: a case-control study.

The Common Carotid artery Intima-Media Thickness (CCIMT) can reflect systemic atherosclerosis in renal patients on hemodialysis. This study aimed to compare CCIMT measured by color Doppler ultrasonography between two groups including dialytic patients and normal subjects. In this case-control setting, 48 patients with Chronic Kidney Disease (CKD) on hemodialysis (case group) and 46 age and sex-matched healthy subjects (control group) were enrolled in this study. Color Doppler ultrasound was used to measure CCIMT and determine presence of atherosclerotic plaques in carotid bulb in both groups. Various laboratory parameters were also determined. Serum levels of triglyceride, total cholesterol, low-density lipoprotein, fasting sugar, ionized calcium, inorganic phosphorus and magnesium were comparable between the two groups. Hypertension and elevated levels of serum C-reactive protein, as well as the mean levels of serum non-fasting homocysteine and phosphate were significantly higher in the case group. Mean levels of serum high-density lipoprotein and albumin were significantly higher in the controls. Mean maximum CCIMT was significantly higher in the case group than in controls (0.73 +/- 0.15 vs. 0.68 +/- 0.08 mm, p = 0.01) even after adjusting for other confounding variables. Frequency of patients with atherosclerotic plaques in carotid bulbs was not significantly different between case and controls. In conclusion, this study showed that CCIMT is significantly higher in CKD patients on hemodialysis comparing with matched normal counterparts. Furthermore, this difference was independent of other conventional risk factors for atherosclerosis.