Detalhe da pesquisa
1.
Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.
Bioorg Med Chem
; 28(22): 115723, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33007547
2.
Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase.
Bioorg Med Chem Lett
; 29(15): 1918-1921, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31176700
3.
Development of a RapidFire mass spectrometry assay and a fluorescence assay for the discovery of kynurenine aminotransferase II inhibitors to treat central nervous system disorders.
Anal Biochem
; 501: 56-65, 2016 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26874021
4.
Mechanism of inhibition for BMS-791325, a novel non-nucleoside inhibitor of hepatitis C virus NS5B polymerase.
J Biol Chem
; 289(48): 33456-68, 2014 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25301950
5.
Corrigendum to "Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase" [Bioorg. Med. Chem. Lett. 29 (2019) 1918-1921].
Bioorg Med Chem Lett
; 29(17): 2525, 2019 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31353296
6.
Nonclinical toxicology assessments support the chronic safety of dapagliflozin, a first-in-class sodium-glucose cotransporter 2 inhibitor.
Int J Toxicol
; 32(5): 336-50, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24097127
7.
Understanding intra-abdominal hypertension: from the bench to the bedside.
J Intensive Care Med
; 27(3): 145-60, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-21525112
8.
Dissecting the activation of thienopyridines by cytochromes P450 using a pharmacodynamic assay in vitro.
J Pharmacol Exp Ther
; 339(2): 589-96, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21828263
9.
Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo.
J Med Chem
; 63(4): 1660-1670, 2020 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31990537
10.
Potent Triazolopyridine Myeloperoxidase Inhibitors.
ACS Med Chem Lett
; 9(12): 1175-1180, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613322
11.
Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.
ACS Med Chem Lett
; 9(12): 1263-1268, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613337
12.
PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor.
ACS Med Chem Lett
; 9(7): 673-678, 2018 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30034599
13.
Triazolopyrimidines identified as reversible myeloperoxidase inhibitors.
Medchemcomm
; 8(11): 2093-2099, 2017 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108726
14.
Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist.
J Med Chem
; 56(22): 9275-95, 2013 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24164581
15.
Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.
J Med Chem
; 56(4): 1704-14, 2013 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23368907
16.
Anion gap, anion gap corrected for albumin, and base deficit fail to accurately diagnose clinically significant hyperlactatemia in critically ill patients.
J Intensive Care Med
; 23(2): 122-7, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18431828
17.
Development and validation of a platelet calcium flux assay using a fluorescent imaging plate reader.
Anal Biochem
; 357(2): 216-24, 2006 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16889745