Detalhe da pesquisa
1.
Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer.
Cell
; 175(5): 1244-1258.e26, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30454645
2.
Effects of a Novel Beta Lactam Compound, MC-100093, on the Expression of Glutamate Transporters/Receptors and Ethanol Drinking Behavior of Alcohol-Preferring Rats.
J Pharmacol Exp Ther
; 383(3): 208-216, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36153003
3.
MC-100093, a Novel ß-Lactam Glutamate Transporter-1 Enhancer Devoid of Antimicrobial Properties, Attenuates Cocaine Relapse in Rats.
J Pharmacol Exp Ther
; 378(2): 51-59, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33986035
4.
Targeting SARS-CoV-2 M3CLpro by HCV NS3/4a Inhibitors: In Silico Modeling and In Vitro Screening.
J Chem Inf Model
; 61(2): 1020-1032, 2021 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33538596
5.
Discovery of Novel Small-Molecule Inhibitors of SARS-CoV-2 Main Protease as Potential Leads for COVID-19 Treatment.
J Chem Inf Model
; 61(9): 4745-4757, 2021 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34403259
6.
Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents.
Bioorg Med Chem
; 42: 116251, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34116381
7.
Novel compounds that reverse the disease phenotype in Type 2 Gaucher disease patient-derived cells.
Bioorg Med Chem Lett
; 30(2): 126806, 2020 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31757667
8.
Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin.
Bioorg Med Chem Lett
; 28(6): 1127-1131, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29463447
9.
Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17α-hydroxylase-C17,20-lyase (Cyp17).
Bioorg Med Chem Lett
; 28(13): 2270-2274, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29803730
10.
Nuclear Magnetic Resonance Structure of the Human Polyoma JC Virus Agnoprotein.
J Cell Biochem
; 118(10): 3268-3280, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28295503
11.
Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3Kα/mTOR inhibitors.
Bioorg Med Chem Lett
; 27(14): 3117-3122, 2017 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28571824
12.
Emerging From the Unknown: Structural and Functional Features of Agnoprotein of Polyomaviruses.
J Cell Physiol
; 231(10): 2115-27, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26831433
13.
Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome.
Bioorg Med Chem Lett
; 26(23): 5825-5829, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27789139
14.
Small-molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing.
Antimicrob Agents Chemother
; 59(4): 2016-28, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25605356
15.
Nuclear magnetic resonance structure revealed that the human polyomavirus JC virus agnoprotein contains an α-helix encompassing the Leu/Ile/Phe-rich domain.
J Virol
; 88(12): 6556-75, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24672035
16.
Heterocyclic chalcone activators of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) with improved in vivo efficacy.
Bioorg Med Chem
; 23(17): 5352-9, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26278028
17.
Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication.
Bioorg Med Chem
; 22(3): 1148-55, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24405813
18.
Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol.
Brain Res Bull
; 211: 110935, 2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38570076
19.
MC180295 is a highly potent and selective CDK9 inhibitor with preclinical in vitro and in vivo efficacy in cancer.
Clin Epigenetics
; 16(1): 3, 2024 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38172923
20.
A novel monobactam lacking antimicrobial activity, MC-100093, reduces sex-specific ethanol preference and depressive-like behaviors in mice.
Neuropharmacology
; 232: 109515, 2023 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37001726