Detalhe da pesquisa
1.
miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy.
Hum Mol Genet
; 30(1): 103-118, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33555315
2.
A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone.
FASEB J
; 34(6): 7234-7246, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32347987
3.
Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress.
FASEB J
; 34(2): 2087-2104, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31907991
4.
Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.
J Neurosci
; 35(6): 2358-71, 2015 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25673831
5.
The neuroprotective effect of Klotho is mediated via regulation of members of the redox system.
J Biol Chem
; 289(35): 24700-15, 2014 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-25037225
6.
PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.
Ann Neurol
; 76(3): 379-92, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043464
7.
The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.
J Neurosci
; 33(5): 1927-39, 2013 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23365232
8.
Identification of cleavage sites leading to the shed form of the anti-aging protein klotho.
Biochemistry
; 53(34): 5579-87, 2014 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25110992
9.
Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk.
J Biol Chem
; 288(51): 36302-11, 2013 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24217253
10.
The spectrum of disease in chronic traumatic encephalopathy.
Brain
; 136(Pt 1): 43-64, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23208308
11.
Identification of novel small molecules that elevate Klotho expression.
Biochem J
; 441(1): 453-61, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21939436
12.
Differential toxicity profile of secreted and processed α-Klotho expression over mineral metabolism and bone microstructure.
Sci Rep
; 13(1): 4211, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36918615
13.
Knockout of the longevity gene Klotho perturbs aging- and Alzheimer's disease-linked brain microRNAs and tRNA fragments.
bioRxiv
; 2023 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37745362
14.
Aging-suppressor Klotho: Prospects in diagnostics and therapeutics.
Ageing Res Rev
; 82: 101766, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36283617
15.
A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy.
Cancers (Basel)
; 13(24)2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34944918
16.
Klotho, PTSD, and advanced epigenetic age in cortical tissue.
Neuropsychopharmacology
; 46(4): 721-730, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33096543
17.
Cell-type dependent modulation of Notch signaling by the amyloid precursor protein.
J Neurochem
; 113(1): 262-74, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20089128
18.
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17.
Proc Natl Acad Sci U S A
; 104(50): 19796-801, 2007 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18056631
19.
Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho.
PLoS One
; 15(1): e0226382, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31929539
20.
PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation.
Psychoneuroendocrinology
; 117: 104656, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32438247