Detalhe da pesquisa
1.
Identification of predictive genetic signatures of Cytarabine responsiveness using a 3D acute myeloid leukaemia model.
J Cell Mol Med
; 23(10): 7063-7077, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31449347
2.
Spatial and temporal studies of metabolic activity: contrasting biochemical kinetics in tissues and pathways during fasted and fed states.
Am J Physiol Endocrinol Metab
; 316(6): E1105-E1117, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30912961
3.
Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.
Bioorg Med Chem Lett
; 27(9): 2069-2073, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284804
4.
Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.
Bioorg Med Chem Lett
; 27(9): 2063-2068, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284809
5.
Development of a fluorescence polarization binding assay for folate receptor.
Anal Biochem
; 432(2): 59-62, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23022041
6.
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
J Med Chem
; 65(7): 5675-5689, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35332774
7.
STimulator of INterferon Genes Agonism Accelerates Antitumor Activity in Poorly Immunogenic Tumors.
Mol Cancer Ther
; 21(2): 282-293, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34815361
8.
Establishing and Validating Cellular Functional Target Engagement Assay for Selective IRAK4 Inhibitor Discovery.
SLAS Discov
; 26(8): 1040-1054, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34130529
9.
Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors.
SLAS Discov
; 26(1): 88-99, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32844715
10.
PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.
J Lipid Res
; 51(9): 2611-8, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20453200
11.
Biochemical characterization of cholesteryl ester transfer protein inhibitors.
J Lipid Res
; 51(9): 2739-52, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20458119
12.
An orally available non-nucleotide STING agonist with antitumor activity.
Science
; 369(6506)2020 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32820094
13.
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol
; 27(1): 32-40.e3, 2020 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31653597
14.
Identification of DGAT2 Inhibitors Using Mass Spectrometry.
J Biomol Screen
; 21(2): 117-26, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26403520
15.
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol
; 28(2): 243, 2021 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33607006
16.
Low chemical specificity of the nicotinic acetylcholine receptor sterol activation site.
Biochim Biophys Acta
; 1609(2): 177-82, 2003 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-12543379
17.
Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors.
J Med Chem
; 58(23): 9345-53, 2015 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26561979
18.
The location and nature of general anesthetic binding sites on the active conformation of firefly luciferase; a time resolved photolabeling study.
PLoS One
; 7(1): e29854, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22272253
19.
Geometric isomers of a photoactivable general anesthetic delineate a binding site on adenylate kinase.
J Biol Chem
; 277(28): 25685-91, 2002 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-11976328
20.
Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase Cdelta.
J Biol Chem
; 279(36): 37964-72, 2004 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15234976