Detalhe da pesquisa
1.
Distinct clinical phenotypes for Crohn's disease derived from patient surveys.
BMC Gastroenterol
; 21(1): 160, 2021 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33836648
2.
A probabilistic pathway score (PROPS) for classification with applications to inflammatory bowel disease.
Bioinformatics
; 34(6): 985-993, 2018 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29048458
3.
Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676.
J Pharmacol Exp Ther
; 358(3): 464-71, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27402278
4.
Cytochrome p450 inhibitory properties of common efflux transporter inhibitors.
Drug Metab Dispos
; 42(3): 441-7, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24396142
5.
Functional ATP-binding cassette drug efflux transporters in isolated human and rat hepatocytes significantly affect assessment of drug disposition.
Drug Metab Dispos
; 42(3): 448-58, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24396144
6.
Prediction of in vivo rat biliary drug clearance from an in vitro hepatocyte efflux model.
Drug Metab Dispos
; 42(3): 459-68, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24396143
7.
The impact of solute carrier (SLC) drug uptake transporter loss in human and rat cryopreserved hepatocytes on clearance predictions.
Drug Metab Dispos
; 42(3): 469-80, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24396146
8.
Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes.
Xenobiotica
; 42(9): 841-53, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22509824
9.
Mendelian Disease Associations Reveal Novel Insights into Inflammatory Bowel Disease.
Inflamm Bowel Dis
; 24(3): 471-481, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29462399
10.
Mucosal Gene Expression in Pediatric and Adult Patients With Ulcerative Colitis Permits Modeling of Ideal Biopsy Collection Strategy for Transcriptomic Analysis.
Inflamm Bowel Dis
; 24(12): 2565-2578, 2018 11 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-30085215
11.
Novel aspects of drug metabolism and transport.
Drug News Perspect
; 19(10): 637-51, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17299607
12.
Predicting drug metabolism: a site of metabolism prediction tool applied to the cytochrome P450 2C9.
J Med Chem
; 46(12): 2313-24, 2003 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12773036
13.
Conformer- and alignment-independent model for predicting structurally diverse competitive CYP2C9 inhibitors.
J Med Chem
; 47(4): 907-14, 2004 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-14761192
14.
State-of-the-art tools for computational site of metabolism predictions: comparative analysis, mechanistical insights, and future applications.
Drug Metab Rev
; 39(1): 61-86, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17364881
15.
Comparison of methods for the prediction of the metabolic sites for CYP3A4-mediated metabolic reactions.
Drug Metab Dispos
; 34(6): 976-83, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16540587
16.
Discriminant and quantitative PLS analysis of competitive CYP2C9 inhibitors versus non-inhibitors using alignment independent GRIND descriptors.
J Comput Aided Mol Des
; 16(7): 443-58, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12510879
17.
Structural analysis of CYP2C9 and CYP2C5 and an evaluation of commonly used molecular modeling techniques.
Drug Metab Dispos
; 32(11): 1218-29, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15483192