Detalhe da pesquisa
1.
RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation.
Mol Cell
; 82(22): 4262-4276.e5, 2022 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36347258
2.
Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins.
Proc Natl Acad Sci U S A
; 119(1)2022 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34983849
3.
Anionic Lipids Impact RAS-Binding Site Accessibility and Membrane Binding Affinity of CRAF RBD-CRD.
Biophys J
; 119(3): 525-538, 2020 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32649863
4.
KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner.
Biophys J
; 116(6): 1049-1063, 2019 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30846362
5.
The Interplay between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt.
J Biol Chem
; 292(1): 251-263, 2017 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27872186
6.
The small molecule BI-2852 induces a nonfunctional dimer of KRAS.
Proc Natl Acad Sci U S A
; 117(7): 3363-3364, 2020 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32047043
7.
Structural and Biophysical Characterization of the Interactions between Calmodulin and the Pleckstrin Homology Domain of Akt.
J Biol Chem
; 290(45): 27403-27413, 2015 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26391397
8.
Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane.
Commun Biol
; 7(1): 242, 2024 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38418613
9.
Production and Membrane Binding of N-Terminally Acetylated, C-Terminally Farnesylated and Carboxymethylated KRAS4b.
Methods Mol Biol
; 2262: 105-116, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33977473
10.
Fully Processed Recombinant KRAS4b: Isolating and Characterizing the Farnesylated and Methylated Protein.
J Vis Exp
; (155)2020 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32009649
11.
Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.
Sci Rep
; 9(1): 10512, 2019 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31324887
12.
Author Correction: Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane.
Commun Biol
; 7(1): 445, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38605143