Seroprevalence of Hepatitis B, Hepatitis C, and HIV in children with cancer at diagnosis and following therapy in Turkey: progress within the last 25 years.

AIM: Children with cancer receiving intensive chemotherapy require multiple transfusions and are at increased risk for blood transmittable diseases such as hepatitis B virus (HBV), hepatitis C virus (HBC), and HIV infections. The aim of this study was to investigate the seroprevalence of HBV, HCV, and HIV in children with cancer and to compare the results with findings in our previous cancer studies conducted before the national free HBV vaccination and the HCV screening program in blood banks were established. MATERIAL AND METHODS: Sera from 100 children (51 females, 49 males) with cancer treated between January 2010 and January 2012 who received multiple transfusions were investigated for hepatitis B surface antigen (HBsAg), anti-HBs, anti-HCV, anti-HIV at diagnosis and at the end of treatment. Patients were born after 1998 when the national free hepatitis B vaccination program began. RESULTS: HBsAg, anti-HCV, and anti-HIV seropositivities were 0% at diagnosis and at the end of treatment. Anti-HBs seropositivity was 58% at diagnosis and 42% at the end of treatment. HBsAg seropositivity, which was 0% at the end of treatment, was lower than 10% during 1994-95, and 40% from 1986 to 1989. Anti-HCV was 0% in contrast to 14% between 1994 and 1995. Seventeen patients with anti-HBs seropositivity at diagnosis were found to be seronegative after intensive chemotherapy. CONCLUSION: The nil seroprevalence of anti-HBsAg, anti-HCV, and anti-HIV in this cohort of children with cancer is encouraging. This progress is due to advances in donor screening techniques in blood banks, good hygenic practices, and the national free hepatitis B vaccination program in Turkey.

AMAÇ: Çocukluk çagi kanserlerinde yogun kemoterapi sonrasi kan transfüzyonu gerekliligi artmakta ve buna bagli olarak hepatit B, hepatit C ve HIV gibi enfektif hastaliklarin bulasma olasiligi olusmaktadir. Bu çalismanin amaci çocukluk çagi kanserlerinde hepatit B, hepatit C ve HIV seroprevalansini incelemek ve bu sonuçlari ulusal Hepatit B asilamasi baslamadan önceki ve kan bankalarinda rutin hepatit C virüs (HCV) tarama programlari olmadigi dönemki çalismalarla karsilastirmaktir. GEREÇ VE YÖNTEMLER: Ocak 2010­Ocak 2012 arasi kanser tedavisi gören ve çoklu kereler kan transfüzyonu alan 100 olguda (51 kiz, 49 erkek) tanida ve tedavi sonrasi HBsAg, anti-HBs, anti-HCV ve anti-HIV çalisildi. Hastalarimiz 1998 ve sonrasi dogumlu olup, ayni yil baslatilan ulusal hepatit B asi programina dahil idiler. BULGULAR: HBsAg, anti-HCV ve anti-HIV seropozitifitesi tanida ve tedavi sonu %0 saptandi. Anti-HbS seropozitivitesi tani aninda %58 iken, tedavi sonunda %42 idi. HBsAg seropozitifitesi tedavi sonunda 1986­89'da %40, 1994­95'te %10 iken son çalismamizda %0 olarak bulunarak anlamli fark gösterdi. Anti-HCV ise 1994­95'te saptanan %14'e oranla %0 bulundu. Tanida Anti-HBs'si pozitif olan 17 hastanin kemoterapi sonrasi Anti-HBs'leri negatiflesmesine ragmen hiçbirinde HBV enfeksiyonu gelismedi. ÇIKARIMLAR: Bu sonucun elde edilmesinde en önemli etkenler kan bankalarindaki donör tarama tekniklerinde gelisme, hijyen kosullarinin iyilesmesi ve ulusal ücretsiz hepatit B asi programi olarak düsünülebilir. Bu sonuç, gelismekte olan ülkeler için yol gösterici olacaktir.