Detalhe da pesquisa
1.
Discovery of novel pan-genotypic HCV NS5A inhibitors containing a novel tetracyclic core.
Bioorg Med Chem Lett
; 29(5): 700-706, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30711390
2.
In Vitro Antiviral Profile of Ruzasvir, a Potent and Pangenotype Inhibitor of Hepatitis C Virus NS5A.
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30150466
3.
MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV.
Bioorg Med Chem Lett
; 28(10): 1954-1957, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29653894
4.
Alternative core development around the tetracyclic indole class of HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 26(20): 5132-5137, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27634194
5.
Aryl or heteroaryl substituted aminal derivatives of HCV NS5A inhibitor MK-8742.
Bioorg Med Chem Lett
; 26(15): 3414-20, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27394665
6.
Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 26(16): 4106-11, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27423481
7.
Alkyl substituted aminal derivatives of HCV NS5A inhibitor MK-8742.
Bioorg Med Chem Lett
; 26(15): 3800-5, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27282742
8.
Discovery of potent macrocyclic HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 26(15): 3793-9, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27282743
9.
Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742.
Bioorg Med Chem Lett
; 26(19): 4851-4856, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27568086
10.
Structure-activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors.
Bioorg Med Chem Lett
; 26(21): 5354-5360, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27680588
11.
Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity.
Bioorg Med Chem Lett
; 26(13): 3158-3162, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27180013
12.
Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development.
Bioorg Med Chem Lett
; 26(5): 1475-9, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26850003
13.
Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics.
Bioorg Med Chem
; 22(1): 447-58, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24275348
14.
Discovery of an irreversible HCV NS5B polymerase inhibitor.
Bioorg Med Chem Lett
; 23(24): 6585-7, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24252545
15.
Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase.
Bioorg Med Chem
; 21(7): 2007-17, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23434368
16.
II. Novel HCV NS5B polymerase inhibitors: discovery of indole C2 acyl sulfonamides.
Bioorg Med Chem Lett
; 22(1): 713-7, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22104146
17.
I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles.
Bioorg Med Chem Lett
; 21(18): 5336-41, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21840715
18.
Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides.
Bioorg Med Chem Lett
; 20(7): 2119-24, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20219368
19.
Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases.
J Med Chem
; 63(5): 2411-2425, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32101422
20.
Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions.
J Med Chem
; 61(9): 3984-4003, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29681153