Detalhe da pesquisa
1.
Preclinical characterization and IND-enabling safety studies for PNT001, an antibody that recognizes cis-pT231 tau.
Alzheimers Dement
; 19(10): 4662-4674, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37002928
2.
Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite.
Bioorg Med Chem Lett
; 30(22): 127530, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32890687
3.
A Functional NaV1.7-NaVAb Chimera with a Reconstituted High-Affinity ProTx-II Binding Site.
Mol Pharmacol
; 92(3): 310-317, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28645932
4.
Development of a spontaneously active dorsal root ganglia assay using multiwell multielectrode arrays.
J Neurophysiol
; 115(6): 3217-28, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27052585
5.
The γ-Secretase Modulator, BMS-932481, Modulates Aß Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers.
J Pharmacol Exp Ther
; 358(1): 138-50, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27189973
6.
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.
J Pharmacol Exp Ther
; 358(1): 125-37, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27189974
7.
Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors.
Bioorg Med Chem Lett
; 26(23): 5729-5731, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27816517
8.
Exploring the Therapeutic Potential of Phosphorylated Cis-Tau Antibody in a Pig Model of Traumatic Brain Injury.
Biomedicines
; 11(7)2023 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37509447
9.
USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
Life Sci Alliance
; 3(8)2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32636217
10.
APP processing is regulated by cytoplasmic phosphorylation.
J Cell Biol
; 163(1): 83-95, 2003 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-14557249
11.
Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 19(19): 5703-7, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19700321
12.
Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481.
ACS Med Chem Lett
; 10(3): 312-317, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891132
13.
A randomized, single ascending dose study of intravenous BIIB092 in healthy participants.
Alzheimers Dement (N Y)
; 4: 746-755, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30581980
14.
Synergistic inhibition of Aß production by combinations of γ-secretase modulators.
Eur J Pharmacol
; 812: 104-112, 2017 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28690193
15.
Dramatic elevation in urinary amino terminal titin fragment excretion quantified by immunoassay in Duchenne muscular dystrophy patients and in dystrophin deficient rodents.
Neuromuscul Disord
; 27(7): 635-645, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28554556
16.
B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor.
Eur J Pharmacol
; 799: 16-25, 2017 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28132910
17.
40 Hz Auditory Steady-State Response Is a Pharmacodynamic Biomarker for Cortical NMDA Receptors.
Neuropsychopharmacology
; 41(9): 2232-40, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26837462
18.
Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine ß-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors.
J Med Chem
; 59(18): 8593-600, 2016 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27559936
19.
Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aß Reduction in Rodents.
ACS Med Chem Lett
; 7(3): 271-6, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985314
20.
Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene.
J Neurosci
; 23(7): 2769-78, 2003 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12684463