1.
Chem Commun (Camb)
; 58(89): 12475-12478, 2022 Nov 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36274265
RESUMO
An alpha helical turn can be reproduced in a cyclic pentapeptide if the first and fifth amino acid sidechains are correctly joined. Here structural studies (CD, NMR, in silico) reveal why N-methylation at positions not involved in hydrogen bonds disrupts helicity whereas ester bonds can maintain helicity and promote greater cell uptake.