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1.
Environ Res ; 251(Pt 2): 118687, 2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38493853

RESUMO

The current study had conducted the life cycle analysis (LCA) to assess the environmental impact of microalgal wastewater treatment via an integrated membrane bioreactor. The functional unit selected for this analysis was 1 kg of treated microalgal wastewater with contaminants eliminated by ultrafiltration membrane fabricated from recycled polyethylene terephthalate waste. Meanwhile, the applied system boundary in this study was distinguished based on two scenarios, namely, cradle-to-gate encompassed wastewater treatment only and cradle-to-cradle which included the reutilization of treated wastewater to cultivate microalgae again. The environmental impacts and hotspots associated with the different stages of the wastewater treatment process had clearly elucidated that membrane treatment had ensued the highest impact, followed by microalgal harvesting, and finally cultivation. Among the environmental impact categories, water-related impact was found to be prominent in the following series: freshwater ecotoxicity, freshwater eutrophication and marine ecotoxicity. Notably, the key performance indicator of all environmental impact, i.e., the global warming potential was found to be very much lower at 2.94 × 10-4 kg CO2 eq as opposed to other literatures reported on the LCA of wastewater treatments using membranes. Overall, this study had proffered insights into the environmental impact of microalgal wastewater treatment and its stimulus for sustainable wastewater management. The findings of this study can be instrumental in making informed decision for optimizing microalgal wastewater treatment and reutilization assisted by membrane technology with an ultimate goal of enhancing sustainability.


Assuntos
Membranas Artificiais , Microalgas , Polietilenotereftalatos , Ultrafiltração , Águas Residuárias , Polietilenotereftalatos/química , Microalgas/crescimento & desenvolvimento , Ultrafiltração/métodos , Águas Residuárias/química , Águas Residuárias/análise , Eliminação de Resíduos Líquidos/métodos , Meio Ambiente , Reatores Biológicos , Reciclagem
2.
J Environ Manage ; 360: 121138, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38749131

RESUMO

In the pursuit of alternatives for conventional diesel, sourced from non-renewable fossil fuel, biodiesel has gained attentions for its intrinsic benefits. However, the commercial production process for biodiesel is still not sufficiently competitive. This review analyses microalgal lipid, one of the important sources of biodiesel, and its cultivation techniques with recent developments in the technical aspects. In fact, the microalgal lipids are the third generation feedstock, used for biodiesel production after its benefits outweigh that of edible vegetable oils (first generation) and non-edible oils (second generation). The critical factors influencing microalgal growth and its lipid production and accumulation are also discussed. Following that is the internal enhancement for cellular lipid production through genetic engineering. Moreover, the microalgae cultivation data modelling was also rationalized, with a specific focus on growth kinetic models that allow for the prediction and optimization of lipid production. Finally, the machine learning and environmental impact analysis are as well presented as important aspects to consider in fulfilling the prime objective of commercial sustainability to produce microalgal biodiesel.


Assuntos
Biocombustíveis , Lipídeos , Microalgas , Microalgas/metabolismo , Microalgas/crescimento & desenvolvimento , Lipídeos/química
3.
Environ Geochem Health ; 46(3): 111, 2024 Mar 11.
Artigo em Inglês | MEDLINE | ID: mdl-38466501

RESUMO

With the advancement of technologies and growth of the economy, it is inevitable that more complex processes are deployed, producing more heterogeneous wastewater that comes from biomedical, biochemical and various biotechnological industries. While the conventional way of wastewater treatment could effectively reduce the chemical oxygen demand, pH and turbidity of wastewater, trace pollutants, specifically the endocrine disruptor compounds (EDCs) that exist in µg L-1 or ng L-1 have further hardened the detection and removal of these biochemical pollutants. Even in small amounts, EDC could interfere human's hormone, causing severe implications on human body. Hence, this review elucidates the recent insights regarding the effectiveness of an advanced 2D material based on titanium carbide (Ti3C2Tx), also known as MXene, in detecting and removing EDCs. MXene's highly tunable feature also allows its surface chemistry to be adjusted by adding chemicals with different functional groups to adsorb different kinds of EDCs for biochemical pollution mitigation. At the same time, the incorporation of MXene into sample matrices also further eases the analysis of trace pollutants down to ng L-1 levels, thereby making way for a more cleaner and comprehensive wastewater treatment. In that sense, this review also highlights the progress in synthesizing MXene from the conventional method to the more modern approaches, together with their respective key parameters. To further understand and attest to the efficacy of MXene, the limitations and current gaps of this potential agent are also accentuated, targeting to seek resolutions for a more sustainable application.


Assuntos
Disruptores Endócrinos , Poluentes Ambientais , Metais Pesados , Nitritos , Elementos de Transição , Poluentes Químicos da Água , Humanos , Água/análise , Águas Residuárias , Disruptores Endócrinos/análise , Metais Pesados/análise , Poluentes Ambientais/análise , Poluentes Químicos da Água/análise
4.
Environ Res ; 231(Pt 2): 116102, 2023 08 15.
Artigo em Inglês | MEDLINE | ID: mdl-37196688

RESUMO

Perfluoroalkyl carboxylic acids (PFCAs) are sub-class of perfluoroalkyl substances commonly detected in water matrices. They are persistent in the environment, hence highly toxic to living organisms. Their occurrence at trace amount, complex nature and prone to matrix interference make their extraction and detection a challenge. This study consolidates current advancements in solid-phase extraction (SPE) techniques for the trace-level analysis of PFCAs from water matrices. The advantages of the methods in terms of ease of applications, low-cost, robustness, low solvents consumption, high pre-concentration factors, better extraction efficiency, good selectivity and recovery of the analytes have been emphasized. The article also demonstrated effectiveness of some porous materials for the adsorptive removal of the PFCAs from the water matrices. Mechanisms of the SPE/adsorption techniques have been discussed. The success and limitations of the processes have been elucidated.


Assuntos
Fluorocarbonos , Poluentes Químicos da Água , Humanos , Água , Fluorocarbonos/análise , Ácidos Carboxílicos/análise , Adsorção , Extração em Fase Sólida/métodos , Poluentes Químicos da Água/análise
5.
Luminescence ; 38(7): 999-1010, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35997211

RESUMO

Nanomaterials are gaining enormous interests due to their novel applications that have been explored nearly in every field of our contemporary society. In this scenario, preparations of nanomaterials following green routes have attracted widespread attention in terms of sustainable, reliable, and environmentally friendly practices to produce diverse nanostructures. In this review, we summarize the fundamental processes and mechanisms of green synthesis approaches of TiO2 nanoparticles (NPs). We explore the role of plants and microbes as natural bioresources to prepare TiO2 NPs. Particularly, focus has been made to explore the potential of TiO2 -based nanomaterials to design a variety of sensing platforms by exploiting the photocatalysis efficiency under the influence of a light source. These types of sensing are of massive importance for monitoring environmental pollution and therefore for inventing advanced strategies to remediate hazardous pollutants and offer a clean environment.


Assuntos
Nanopartículas , Nanoestruturas , Nanotecnologia , Nanoestruturas/química , Poluição Ambiental
6.
J Environ Manage ; 347: 119195, 2023 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-37797519

RESUMO

Since bettering environmental conditions has acquired significant interest globally, discovering factors that may facilitate the establishment of environmental sustainability is currently of foremost importance. Hence, this study considers a sample of 33 members of the Organization for Economic Cooperation and Development and checks whether reducing exposure to different forms of country risks, in the presence of international trade and clean energy consumption, can reduce their respective carbon footprint levels. Utilizing annual data from 2000 to 2018 and employing methods that handle problems related to dependence across cross-sectional units and heterogeneity of slope coefficients, the findings endorse that (a) reducing financial and political risks abate carbon footprints, (b) economic risk exposure does not influence carbon footprints, (c) international trade exerts carbon footprint-boosting effects, and (d) undergoing unclean to clean energy transition curbs carbon footprints. Accordingly, the concerned governments should these findings into account while conceptualizing green environmental policies in the future.


Assuntos
Pegada de Carbono , Comércio , Internacionalidade , Estudos Transversais , Desenvolvimento Econômico , Dióxido de Carbono , Energia Renovável
7.
J Environ Manage ; 348: 119381, 2023 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-37864938

RESUMO

World's highest arsenic (As) contamination is well-documented for the groundwater system of southwestern region (mainly Jashore district) of Bangladesh, where the majority of inhabitants are underprivileged. To mitigate As poisoning in southwestern Bangladesh, numerous steps have been taken so far by the government and non-governmental organizations (NGOs). Among them, digging deep tube wells and As removal by naturally deposited Fe(OH)3 species are being widely practiced in the contaminated areas. However, these actions have been left unmonitored for decades, making people unaware of this naturally occurring deadly poison in their drinking water. Hence, water samples (n = 63, both treated and untreated) and soil samples (n = 4) were collected from different spots in Jashore district to assess the safety level of drinking water and to understand the probable reasons for high As(III) contamination. About 93.7% of samples were found to contain As(III) above 10 µg/L; among them, 38% contained above 50 µg/L. The study shows that current As(III) removal strategies in the study area are ineffective. In this connection, a simple low-cost As(III) removal adsorbent is proposed that can be prepared with very cheap and locally available materials like iron sludge and charcoal. The adsorbent was characterized in terms of SEM, EDX, and XPS. The optimal dosage of the adsorbent was investigated for real-life application concerning several vital water quality parameters. The Fe-C adsorbent exhibited a maximum As(III) removal efficiency of 92% in real groundwater samples. The study will allow policymakers for informed decision-making regarding water body management as well as enable the local people to avail As-safe water in a way that aligns with their economic factors.


Assuntos
Arsênio , Água Potável , Água Subterrânea , Poluentes Químicos da Água , Purificação da Água , Humanos , Monitoramento Ambiental , Arsênio/análise , Bangladesh , Análise Custo-Benefício , Poluentes Químicos da Água/análise
8.
Molecules ; 26(6)2021 Mar 17.
Artigo em Inglês | MEDLINE | ID: mdl-33802860

RESUMO

The COVID-19 outbreak continues to spread worldwide at a rapid rate. Currently, the absence of any effective antiviral treatment is the major concern for the global population. The reports of the occurrence of various point mutations within the important therapeutic target protein of SARS-CoV-2 has elevated the problem. The SARS-CoV-2 main protease (Mpro) is a major therapeutic target for new antiviral designs. In this study, the efficacy of PF-00835231 was investigated (a Mpro inhibitor under clinical trials) against the Mpro and their reported mutants. Various in silico approaches were used to investigate and compare the efficacy of PF-00835231 and five drugs previously documented to inhibit the Mpro. Our study shows that PF-00835231 is not only effective against the wild type but demonstrates a high affinity against the studied mutants as well.


Assuntos
Antivirais/química , Antivirais/farmacologia , Proteases 3C de Coronavírus/antagonistas & inibidores , Indóis/química , Indóis/farmacologia , Leucina/química , Leucina/farmacologia , Inibidores de Proteases/química , Inibidores de Proteases/farmacologia , Pirrolidinonas/química , Pirrolidinonas/farmacologia , Sítios de Ligação , Simulação por Computador , Proteases 3C de Coronavírus/química , Proteases 3C de Coronavírus/genética , Bases de Dados de Proteínas , Diarilquinolinas/química , Diarilquinolinas/farmacologia , Di-Hidropiridinas/química , Di-Hidropiridinas/farmacologia , Humanos , Ligantes , Simulação de Acoplamento Molecular , Simulação de Dinâmica Molecular , Nitrobenzenos/química , Nitrobenzenos/farmacologia , Nitrofenóis/química , Nitrofenóis/farmacologia , Compostos Organofosforados/química , Compostos Organofosforados/farmacologia , Piperazinas/química , Piperazinas/farmacologia , Prolina/análogos & derivados , Prolina/química , Prolina/farmacologia , SARS-CoV-2/efeitos dos fármacos , SARS-CoV-2/genética , Tratamento Farmacológico da COVID-19
9.
Molecules ; 26(1)2021 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-33401536

RESUMO

BACKGROUND: The red-complex bacteria are one of the most significant complexes found simultaneously in subgingival plaque next to the periodontal pocket. The current antibacterial treatment is not adequate, and multidrug resistance to it is developing. Henceforth, the antibacterial effect of the ethanolic extract of Nepeta deflersiana was put to test against red-complex bacteria in patients with chronic periodontitis. METHODS: Well diffusion and micro broth dilution procedure by Alamar blue were applied to assess the zone of inhibition (ZOI), the minimum inhibitory concentration (MIC), and the minimum bactericidal concentration (MBC). Anti-virulence efficacies of the plant extract that comprise of adherence and formation of biofilms were examined by the process of adherence and biofilm production assay. RESULTS: The crude extract of Nepeta deflersiana exhibited significant inhibitory outcome against periodontopathic bacteria with noteworthy MIC (0.78-3.12 mg/mL), inhibitory zone (12-20 mm), as well as MBC (3.12-12.50 mg/mL). The N. deflersiana extract inhibited bacterial adhesion ranging from 41% to 52%, 53% to 66%, and 60% to 79% at the given MIC × 0.5, MIC × 1, and MIC × 2 in succession. Substantial suppression was also developed in the biofilm production of the investigated periodontopathic strains following exposure to numerous concentrations of N. deflersianan extract for a period of 24 and 48 h. CONCLUSION: These outcomes divulge a new concept that N. deflersiana extract can be utilized to manufacture valuable antibacterial compounds to treat chronic and acute periodontitis. This identifies N. deflersiana as an essential natural source for future drug development.


Assuntos
Antibacterianos , Bactérias/crescimento & desenvolvimento , Microbiota/efeitos dos fármacos , Nepeta/química , Doenças Periodontais/microbiologia , Extratos Vegetais , Antibacterianos/química , Antibacterianos/farmacologia , Humanos , Doenças Periodontais/tratamento farmacológico , Extratos Vegetais/química , Extratos Vegetais/farmacologia
10.
Saudi Pharm J ; 28(10): 1203-1209, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33132714

RESUMO

BACKGROUND: Chronic periodontitis has an interplay between different species of bacteria found in dental biofilms act a crucial role in pathogenesis and disease progression. The existing antibacterial therapy is inadequate, associated with many side effects as well as evolving multidrug resistance. Hence, novel drugs development with minimum or no toxicity is an immediate priority. METHODS: Antibacterial efficacy of ethanolic extract of Matricaria aurea was tested against clinical isolates, ie. Treponema denticol, Tannerella forsythia, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis from the patients with chronic periodontitis. Zone of inhibition, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were investigated by well diffusion method and micro broth dilution assay using alamar blue. Anti-virulence properties of the extract, which include adherence property and the biofilm formation, were investigated by adherence as well as biofilm formation assay. RESULTS: Matricaria aurea extract showed potent inhibitory effect against pathogenic periodontal bacteria with the significant inhibitory zone (13-23 mm), MIC (0.39-1.56 mg/ml) as well as MBC (1.56-6.25 mg/ml). The M. aurea extract was able to inhibit bacterial adhesion ranged from 30 to 45%, 35 to 63% and 55 to 80% of MIC at MIC × 0.5, MIC × 1 and MIC × 2 respectively. Significant inhibition was found in biofilm formation to all the tested periodontal bacterial strains after the treatment with various concentrations of M. aurea extract for 24 and 48hrs. CONCLUSION: These results reveal for the first time that the Matricaria aurea extract might be the source of various compounds to be applied for chronic periodontitis therapy, which might draw these valuable compounds to the subsequent phase of development of the drug.

11.
ACS Omega ; 9(1): 1174-1182, 2024 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-38222620

RESUMO

Immune cell infiltration is associated with improved prognosis in the microenvironment of breast cancer. The incidence of breast cancer in Pakistan is 2.5 times higher than that in neighboring countries of Asia, accounting for 34.6% of female cancers. The objectives of this study were to compare and determine apoptotic mediators and biomarkers for breast carcinoma, such as serum granzyme B, cytochrome C, and vitamin D by ELIZA and calcium spectrophotometrically. Study groups were differentiated into malignant breast disease G-I, benign proliferative breast disease G-II, and healthy control group G-III. The immune-related prognostic markers and therapeutic targets were determined through the interaction of proteins by molecular docking and AutoDock Vina software. The level of granzyme B and cyt C was higher in Group-I, -II, and -III. Likewise, the mean vitamin D level was greater in Group-I than those in other groups. Through SwissDock, the proteins granzyme B and cyt C with vitamin D, single amino acid residue MET34 (H-bond 2.75 Å), and ILE81(H-bond 2.092 Å) were revealed to actively participate in interactions. This study reveals granzyme B and cyt C as biomarkers for malignant breast disease and benign proliferative breast disease, while hypovitaminosis D and hypocalcemia are complications or comorbidities of breast cancer.

12.
ACS Omega ; 9(7): 7643-7657, 2024 Feb 20.
Artigo em Inglês | MEDLINE | ID: mdl-38405447

RESUMO

A novel application of the Pistacia integerrima gall extract as an environmentally friendly corrosion inhibitor is reported in this study. The major phytochemicals present in the gall extract, namely pistagremic acid, ß-sitosterol, pistiphloroglucinyl ether, pistaciaphenyl ester, naringenin, and 5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one, play key roles in its anticorrosive behavior on steel in aggressive media. Several approaches were used to study the corrosion prevention activity of steel in 1 M H2SO4, including weight loss analysis, scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), potentiodynamic polarization (PDP), and density functional theory (DFT). At 2000 mg L-1, the highest efficiency of 92.19% was observed in 1 M H2SO4. An SEM study was conducted to validate the surface coverage of the metal surface. DFT studies revealed several nucleophilic regions present in the phytochemicals of the inhibitor, which supported the favorable nucleophilicity. Corrosion studies have not been performed on this sample. Phytochemicals make it an effective corrosion inhibitor, and its extraction process utilizes distilled water, making it better than other inhibitors. It has been proven that the obtained values of ΔEInhDFT for pistiphloroglucinyl, pistaciaphenyl ether, and naringenin organic compounds were very low, confirming the high reactivity of these corrosion inhibitors. The order of the values of ΔEInhDFT is as follows: pistaciaphenyl ether > pistiphloroglucinyl ether > naringenin organic compound; this suggests that pistaciaphenyl ether is more reactive than the other compounds. In this study, P. integerrima gall extract emerges as a novel and highly effective corrosion resistance agent in 1 M H2SO4, chosen for its relevance to acid pickling and cleaning processes.

13.
Environ Sci Pollut Res Int ; 31(6): 9700-9712, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38194172

RESUMO

The BRICS countries ratified the 2030 Sustainable Development Goals agenda whereby ensuring environmental sustainability is of paramount importance for these emerging market economies. Although the BRICS nations have recorded noteworthy economic growth trajectories over the last couple of decades, these nations have not fared well in terms of improving their environmental indicators, especially due to gradually becoming more fossil fuel dependent over time. Hence, this study aims to explore whether undergoing the renewable energy transition can directly and indirectly establish environmental sustainability in the BRICS countries by containing their annual growth rates of carbon dioxide emissions. Additionally, the emission growth rate-influencing effects of technological innovation, foreign direct investment receipts, urbanization, and institutional quality are also evaluated. Based on data spanning from 1996 to 2021 and considering the result obtained using advanced panel data estimators, the findings endorse that the yearly carbon emission growth rates are (a) unaffected by undergoing the renewable energy transition on its own; (b) positively impacted by technological innovation, net receipts of foreign direct investment, and urbanization; and (c) negatively impacted by improving institutional quality through effective controlling of the spread of corruption. More importantly, the results verify the joint carbon emission growth rate-mitigating impact of renewable energy transition and institutional quality improvement. Hence, for abating the emission growth rate figures, several policies are prescribed.


Assuntos
Desenvolvimento Econômico , Energia Renovável , Dióxido de Carbono , Investimentos em Saúde , Invenções
14.
Sci Rep ; 14(1): 1207, 2024 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-38216633

RESUMO

Heat and mass transfer rate by using nanofluids is a fundamental aspect of numerous industrial processes. Its importance extends to energy efficiency, product quality, safety, and environmental responsibility, making it a key consideration for industries seeking to improve their operations, reduce costs, and meet regulatory requirements. So, the principal objective of this research is to analyze the heat and mass transfer rate for three-dimensional magneto hydrodynamic nanoliquid movement with thermal radiation and chemical reaction over the dual stretchable surface in the existence of an inclined magnetization, and viscous dissipation. The flow is rotating with constant angular speed [Formula: see text] about the axis of rotation because such flows occur in the chemical processing industry and the governing equations of motion, energy, and concentration are changed to ODEs by transformation. The complex and highly nonlinear nature of these equations makes them impractical to solve analytically so tackled numerically at MATLAB. The obtained numerical results are validated with literature and presented through graphs and tables. Increasing the Eckert number from [Formula: see text] a higher Nusselt and Sherwood number was noted for the hybrid nanofluid. By changing the angle of inclination [Formula: see text], the [Formula: see text] performance is noted at 8% for nanofluid and 33% for hybrid nanofluid. At the same time, [Formula: see text] performance of 0.5% and 2.0% are observed respectively. Additionally, as the angle of inclination increases the skin friction decreases and the chemical reaction rate increases the mass transmission rate.

15.
RSC Adv ; 14(10): 6476-6493, 2024 Feb 21.
Artigo em Inglês | MEDLINE | ID: mdl-38390507

RESUMO

The current work is about the modification of primary amine functionalized drugs, pyrimethamine and 4-amino-N-(2,3-dihydrothiazol-2-yl)benzenesulfonamide, via condensation reaction with 2-hydroxy-1-naphthaldehyde to produce new organic zwitterionic compounds (E)-1-(((4-(N-(2,3-dihydrothiazol-2-yl)sulfamoyl)phenyl)iminio)methyl)naphthalen-2-olate (DSPIN) and (E)-1-(((4-amino-5-(4-chlorophenyl)-6-ethylpyrimidin-2-yl)iminio)methyl)naphthalen-2-olate (ACPIN) in methanol as a solvent. The crystal structures of both compounds were confirmed to be imine-based zwitterionic products via single-crystal X-ray diffraction (SC-XRD) analysis which indicated that the stabilization of both crystalline compounds is achieved via various noncovalent interactions. The supramolecular assembly in terms of noncovalent interactions was explored by the Hirshfeld surface analysis. Void analysis was carried out to predict the crystal mechanical response. Compound geometries calculated in the DFT (Density Functional Theory) study showed reasonably good agreement with the experimentally determined structural parameters. Frontier molecular orbital (FMO) analysis showed that the DSPIN HOMO/LUMO gap is by 0.15 eV smaller than the ACPIN HOMO/LUMO gap due to some destabilization of the DSPIN HOMO and some stabilization of its LUMO. The results of the charge analysis implied formation of intramolecular hydrogen bonds and suggested formation of intermolecular hydrogen bonding and dipole-dipole and dispersion interactions.

16.
Infect Genet Evol ; 118: 105559, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38266757

RESUMO

BACKGROUND: In this study, we have identified multiple mutations in the IL-12R1 gene among Pakistani patients who have inherited them through consanguineous marriages. These patients have experienced severe Bacille-Calmette-Guérin (BCG) infection as well as recurrent tuberculosis. We will demonstrate the pivotal role of interleukin (IL)-12/interferon (IFN)-γ axis in the regulation of mycobacterial diseases. METHODOLOGY: First, we checked the patients' medical records, and then afterward, we assessed interferon-gamma (IFN-γ) production through ELISA. Following that, DNA was extracted to investigate IL-12/IFN- abnormalities. Whole exome sequencing was conducted through Sanger sequencing. Secretory cytokine levels were compared from healthy control of the same age groups and they were found to be considerably less in the disease cohort. To evaluate the probable functional impact of these alterations, an in silico study was performed. RESULTS: The study found that the patients' PBMCs produced considerably less IFN-γ than expected. Analysis using flow cytometry showed that activated T cells lacked surface expression of IL-12Rß1. Exon 7 of the IL-12Rß1 gene, which encodes a portion of the cytokine binding region (CBR), and exon 10, which encodes the fibronectin-type III (FNIII) domain, were found to have the mutations c.641 A > G; p.Q214R and c.1094 T > C; p.M365T, respectively. In silico analysis showed that these mutations likely to have a deleterious effect on protein function. CONCLUSION: Our findings indicate the significant contribution of the IL-12/IFN-γ is in combating infections due to mycobacterium. Among Pakistani patients born to consanguineous marriages, the identified mutations in the IL-12Rß-1 gene provide insights into the genetic basis of severe BCG infections and recurrent tuberculosis. The study highlights the potential utility of newborn screening in regions with mandatory BCG vaccination, enabling early detection and intervention for primary immunodeficiencies associated with mycobacterial infections. Moreover, the study suggests at the potential role of other related genes such as IL-23Rß1, TYK2, or JAK2 in IFN-γ production, warranting further investigation.


Assuntos
Vacina BCG , Tuberculose , Recém-Nascido , Humanos , Consanguinidade , Sequenciamento do Exoma , Incidência , Receptores de Interleucina-12/genética , Tuberculose/epidemiologia , Tuberculose/genética , Interleucina-12/genética , Interleucina-12/metabolismo , Citocinas/genética , Interferon gama/metabolismo
17.
Sci Rep ; 13(1): 6287, 2023 Apr 18.
Artigo em Inglês | MEDLINE | ID: mdl-37072422

RESUMO

In various machinery engines, the engine oil is utilized as a lubricant. Heat transportation rate and to saving the energy dissipated due to higher temperature are the basic goals of all thermal systems. Thus, current work is mainly focused to develop a model for the Marangoni flow of nanofluids (NFs) with viscous dissipation. The considered NFs are made of nanoparticles (NPs) i.e. [Formula: see text] and base fluid (BF) as Engine Oil (EO). Darcy Forchheimer (DF) law which leads to porous medium is implemented in the model to investigate the variations of NF velocity and temperature. The governing flow expressions are simplified through similarity variables. The obtained expressions are solved numerically via an effective technique known as the NDSolve algorithm. The consequences of pertinent variables on temperature, velocity and Nusselt number are designed through tables and graphs. The obtained results reveal that velocity rises for higher Marangoni number, Darcy Forchheimer (DF) parameter whereas it shows decaying behavior against nanoparticles volume fraction.

18.
Environ Sci Pollut Res Int ; 30(4): 9699-9712, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36063266

RESUMO

The present study major aim was to examine the impact of globalization, economic growth, population growth, renewable energy usage and nuclear energy on CO2 emissions globally by taking the annual data varies from 1985 to 2020. Stationarity among study variables were tested via unit root testing, while nonlinear autoregressive distributed lag (NARDL) technique was used to demonstrate the linkages among variables with the estimation of long-run and short-run. Study results reveal that both in the short run and long run, negative globalization and economic growth shocks positively and negatively influence CO2 emissions, respectively. Besides, higher population growth is found to positively influence CO2 emissions while renewable energy consumption cannot influence the CO2 emission figures. Lastly, positive and negative shocks to alternative nuclear energy consumption are evidenced to negatively influence CO2 emissions both in the short run and long run. Hence, in line with these findings, several new policies and strategies are recommended for reducing carbon emissions globally.


Assuntos
Dióxido de Carbono , Energia Renovável , Desenvolvimento Econômico , Internacionalidade , Carbono
19.
Math Biosci Eng ; 20(4): 6666-6690, 2023 02 03.
Artigo em Inglês | MEDLINE | ID: mdl-37161123

RESUMO

Monkeypox (MPX) is a global public health concern. This infectious disease affects people all over the world, not just those in West and Central Africa. Various approaches have been used to study epidemiology, the source of infection, and patterns of transmission of MPX. In this article, we analyze the dynamics of MPX using a fractional mathematical model with a power law kernel. The human-to-animal transmission is considered in the model formulation. The fractional model is further reformulated via a generalized fractal-fractional differential operator in the Caputo sense. The basic mathematical including the existence and uniqueness of both fractional and fractal-fractional problems are provided using fixed points theorems. A numerical scheme for the proposed model is obtained using an efficient iterative method. Moreover, detailed simulation results are shown for different fractional orders in the first stage. Finally, a number of graphical results of fractal-fractional MPX transmission models are presented showing the combined effect of fractal and fractional orders on model dynamics. The resulting simulations conclude that the new fractal-fractional operator added more biological insight into the dynamics of illness.


Assuntos
Monkeypox virus , Mpox , Animais , Humanos , Fractais , Simulação por Computador , Saúde Pública
20.
Sci Rep ; 13(1): 5432, 2023 Apr 03.
Artigo em Inglês | MEDLINE | ID: mdl-37012341

RESUMO

The aim of the current analysis is to evaluate the significances of magnetic dipole and heat transmission through ternary hybrid Carreau Yasuda nanoliquid flow across a vertical stretching sheet. The ternary compositions of Al2O3, SiO2, and TiO2 nanoparticles (nps) in the Carreau Yasuda fluid are used to prepare the ternary hybrid nanofluid (Thnf). The heat transfer and velocity are observed in context of heat source/sink and Darcy Forchhemier effect. Mathematically, the flow scenario has been expressed in form of the nonlinear system of PDEs for fluid velocity and energy propagation. The obtained set of PDEs are transform into ODEs through suitable replacements. The obtained dimensionless equations are computationally solved with the help of the parametric continuation method. It has been observed that the accumulation of Al2O3, SiO2 and TiO2-nps to the engine oil, improves the energy and momentum profiles. Furthermore, as compared to nanofluid and hybrid nanofluid, ternary hybrid nanofluid have a greater tendency to boost the thermal energy transfer. The fluid velocity lowers with the outcome of the ferrohydrodynamic interaction term, while enhances with the inclusion of nano particulates (Al2O3, SiO2 and TiO2).

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