Proposed diagnostic criteria for mild cognitive impairment in Down syndrome population.

BACKGROUND: Despite presenting higher risk of dementia, mild cognitive impairment (MCI) is not well defined in Down syndrome population. OBJECTIVE: We aimed to describe cognitive and neuropsychological patterns associated with MCI in Down syndrome individuals. METHOD: Two groups of adults with Down syndrome (control and prodromal) were studied throughout 3 years. Two linear mixed models and a model including the variables that best predicted group membership were built. RESULTS: Behavioural Regulation Index (BRI) (Behaviour Rating Inventory of Executive Function test) and the model composed of BRI, abstraction and delayed verbal memory were the variable and model best predicting group membership, respectively. CONCLUSION: Suggest a diagnosis of MCI when BRI is the earliest change perceived by caregivers and this is combined with low scores in abstract thinking, and when an amnesic pattern in delayed verbal memory is observed, but adaptive skills are preserved.

Wave-induced cross-shore distribution of different densities, shapes, and sizes of plastic debris in coastal environments: A laboratory experiment.

Plastic debris is a significant threat to marine and coastal ecosystems. Previous research found that waves, wind, as well as density, size, and shape of microplastics, drive their transport and dispersion. In this paper, a set of laboratory experiments on the effect of waves and wave-induced currents on the input rate and cross-shore transport and dispersion of different types of plastic debris, including the macro and mesosizes, in addition to microplastics is presented. 15 plastic-debris types characterized by different sizes, shapes, and densities, including facemasks, were analyzed under regular and irregular wave conditions. The results show that input and transport rates of plastics depend on their terminal velocities and wave steepness. Plastics with higher settling velocities under less-steep wave conditions are likely to escape coastal entrapment and end up in the breaking zone. However, plastics with greater buoyancy rates under steeper waves show a predominant accumulation closer to the shoreline.

The Global Deterioration Scale for Down Syndrome Population (GDS-DS): A Rating Scale to Assess the Progression of Alzheimer's Disease.

The aim of this study is to adapt and validate the global deterioration scale (GDS) for the systematic tracking of Alzheimer's disease (AD) progression in a population with Down syndrome (DS). A retrospective dual-center cohort study was conducted with 83 participants with DS (46.65 ± 5.08 years) who formed the primary diagnosis (PD) group: cognitive stability (n = 48), mild cognitive impairment (n = 24), and Alzheimer's disease (n = 11). The proposed scale for adults with DS (GDS-DS) comprises six stages, from cognitive and/or behavioral stability to advanced AD. Two neuropsychologists placed the participants of the PD group in each stage of the GDS-DS according to cognitive, behavioral and daily living skills data. Inter-rater reliability in staging with the GDS-DS was excellent (ICC = 0.86; CI: 0.80-0.93), and the agreement with the diagnosis categories of the PD group ranged from substantial to excellent with κ values of 0.82 (95% CI: 0.73-0.92) and 0.85 (95% CI: 0.72, 0.99). Performance with regard to the CAMCOG-DS total score and orientation subtest of the Barcelona test for intellectual disability showed a slight progressive decline across all the GDS-DS stages. The GDS-DS scale is a sensitive tool for staging the progression of AD in the DS population, with special relevance in daily clinical practice.

A model for describing the eutrophication in a heavily regulated coastal lagoon. Application to the Albufera of Valencia (Spain).

A simplified two-dimensional eutrophication model was developed to simulate temporal and spatial variations of chlorophyll-a in heavily regulated coastal lagoons. This model considers the hydrodynamics of the whole study area, the regulated connexion of the lagoon with the sea, the variability of the input and output nutrient loads, the flux from the sediments to the water column, the phytoplankton growth and mortality kinetics, and the zooplankton grazing. The model was calibrated and validated by applying it to the Albufera of Valencia, a hypertrophic system whose connection to the sea is strongly regulated by a system of sluice-gates. The calibration and validation results presented a significant agreement between the model and the data obtained in several surveys. The accuracy was evaluated using a quantitative analysis, in which the average uncertainty of the model prediction was less than 6%. The results confirmed an expected phytoplankton bloom in April and October, achieving mean maximum values around 250 µg l(-1) of chlorophyll-a. A mass balance revealed that the eutrophication process is magnified by the input loads of nutrients, mainly from the sediments, as well as by the limited connection of the lagoon with the sea. This study has shown that the developed model is an efficient tool to manage the eutrophication problem in heavily regulated coastal lagoons.

[Ekbom syndrome in an intravenous methylphenidate abuser]. / Síndrome de Ekbom en consumidor de metilfenidato intravenoso.

Ekbom syndrome is a mental disorder in which the patient has the monothematic delusion of being infected by parasites. It is an uncommon condition that was initially studied by dermatologists. The exactly etiology is unknown to date, though several causes have been proposed, including metabolic diseases (among other physical causes), psychiatric disorders, drugs, etc. Research has now found a relationship between drug abuse and psychotic symptoms, which appear to be due to altered levels of dopamine at the receptor level. In this article we review the clinical features of the condition and present the case report of an intravenous methylphenidate abuser who developed a delusion of parasitosis.

[Knowledge of PrevenIMSS Programs in users of a primary health care clinic]. / Conocimientos del programa PrevenIMSS en usuarios de una unidad de medicina familiar.

Background: The PrevenIMSS programs are a strategy to promote health self-care at the three levels of prevention, with special emphasis on primary health care. One of its objectives is to have an impact on the morbidity and mortality of chronic non-communicable diseases such as obesity, diabetes and hypertension, the prevention of these illnesses requires knowledge for health self-care contained in these guidelines. Objective: To identify the information that the IMSS beneficiaries have on self-care of health contained in the PrevenIMSS guidelines. Material and methods: Descriptive cross-sectional study. After signing the informed consent, one thousand beneficiaries of a UMF were interviewed, 200 for each PrevenIMSS age group. Questions were asked about: 1. Health promotion, 2. Prevention and control of diseases, 3. Detection of diseases, 4. Nutrition, 5. Sexual and reproductive health, and an open question, to identify their needs for self-care of health. Results: The respondents answered having knowledge about the PrevenIMSS components in: Health promotion: 62%. Nutrition: 43%. Disease prevention: 55.3%. Detection and control of diseases: 51.9%. Sexual and reproductive health: 49.9%. The total score obtained by age group was: 0-9 years 46.35 ± 14.36; 10-19 years 46.02 ± 12.06; women from 20 to 59 years old 46.79 ± 8.19, men from 20 to 59 years old 52.19 ± 14.58; adults aged 60 and over 46.65 ± 13.34. Conclusions: The least information is in nutrition. The group of adolescents was the most affected.

Introducción: los programas PrevenIMSS son una estrategia para promover la salud en los tres niveles de prevención, con especial énfasis en el primer nivel de atención. Uno de sus objetivos es impactar en la morbimortalidad de enfermedades crónicas no transmisibles, como obesidad, diabetes e hipertensión, cuya prevención requiere de conocimientos para el autocuidado de la salud contenidos en estas guías. Objetivo: identificar la información que tienen los derechohabientes del IMSS sobre el autocuidado de la salud contenida en las guías PrevenIMSS. Material y métodos: estudio descriptivo transversal. Previa firma de consentimiento informado se entrevistó a mil derechohabientes de una unidad de medicina familiar; 200 por cada grupo etario PrevenIMSS. Se formularon preguntas acerca de: 1. Promoción de la salud, 2. Prevención y control de enfermedades, 3. Detección de enfermedades, 4. Nutrición, 5. Salud sexual y reproductiva, y una pregunta abierta para identificar sus necesidades sobre el autocuidado de la salud. Resultados: los encuestados respondieron tener conocimientos acerca de los componentes PrevenIMSS en: Promoción de la salud, el 62%; Nutrición, 43%; Prevención de enfermedades, 55.3%; Detección y control de enfermedades, 51.9%, y Salud sexual y reproductiva, 49.9%. El puntaje total obtenido por grupo etario fue: 0-9 años: 46.35 ± 14.36; 10-19 años: 46.02 ± 12.06; mujeres de 20 a 59 años: 46.79 ± 8.19, hombres de 20 a 59 años: 52.19 ±14.58, y adultos mayores de 60 años y más: 46.65 ± 13.34. Conclusiones: la menor información se tiene en nutrición. El grupo de adolescentes fue el más afectado.

The Pictorial Screening Memory Test (P-MIS) for Adults with Moderate Intellectual Disability and Alzheimer's Disease.

In this study, we examined normative data and diagnostic accuracy of a pictorial screening test to detect memory impairment for mild cognitive impairment (MCI) and Alzheimer's disease (AD) in Spanish-speaking adults with intellectual disability (ID). A total of 94 volunteers with ID (60 controls, 17 MCI, and 17 AD), were evaluated by neuropsychological tests including the PMIS-ID in a cross-sectional validation study. Discriminative validity between the MCI, AD, and control group was analyzed by the area under the ROC curve. A cut-off score of 4.5 on the immediate recall trial had a sensitivity of 69% and a specificity of 80% to detect memory impairment (AUC = 0.685; 95% CI = 0.506-0.863) in the AD group. The PMIS-ID is a useful screening test to rule out a diagnosis of memory decline in people with moderate level of ID and AD, and it shows good psychometric properties.

Cognitive training in adults with intellectual disability: pilot study applying a cognitive tele-rehabilitation program.

Introduction: This pilot study analyzes the effect of a cognitive training program in adults with intellectual disability (ID). Method: Twenty subjects (mean age 52.7 ± 9.77 years) with mild and moderate ID were divided in control and experimental group. Only the experimental group received the training program. This program was applied through the GNPT® (Guttmann, NeuroPersonalTrainer®) platform for people with ID. Results: The results revealed a significant improvement in the Kaufman Brief Intelligence Test-2 scores (Matrices subtest) in the experimental group [Z = 2.12; p = .03] after the intervention, indicating an enhancement in fluid ability due to effect of cognitive training program. Conclusion: Findings provide evidence of the importance of applying these programs in a systematized way in adults with ID.

Brain signal complexity in adults with Down syndrome: Potential application in the detection of mild cognitive impairment.

Background: Down syndrome (DS) is considered the most frequent cause of early-onset Alzheimer's disease (AD), and the typical pathophysiological signs are present in almost all individuals with DS by the age of 40. Despite of this evidence, the investigation on the pre-dementia stages in DS is scarce. In the present study we analyzed the complexity of brain oscillatory patterns and neuropsychological performance for the characterization of mild cognitive impairment (MCI) in DS. Materials and methods: Lempel-Ziv complexity (LZC) values from resting-state magnetoencephalography recordings and the neuropsychological performance in 28 patients with DS [control DS group (CN-DS) (n = 14), MCI group (MCI-DS) (n = 14)] and 14 individuals with typical neurodevelopment (CN-no-DS) were analyzed. Results: Lempel-Ziv complexity was lowest in the frontal region within the MCI-DS group, while the CN-DS group showed reduced values in parietal areas when compared with the CN-no-DS group. Also, the CN-no-DS group exhibited the expected pattern of significant increase of LZC as a function of age, while MCI-DS cases showed a decrease. The combination of reduced LZC values and a divergent trajectory of complexity evolution with age, allowed the discrimination of CN-DS vs. MCI-DS patients with a 92.9% of sensitivity and 85.7% of specificity. Finally, a pattern of mnestic and praxic impairment was significantly associated in MCI-DS cases with the significant reduction of LZC values in frontal and parietal regions (p = 0.01). Conclusion: Brain signal complexity measured with LZC is reduced in DS and its development with age is also disrupted. The combination of both features might assist in the detection of MCI within this population.

Hypersynchronized Magnetoencephalography Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer's Disease in Down Syndrome.

Introduction: The majority of individuals with Down syndrome (DS) show signs of Alzheimer's disease (AD) neuropathology in their fourth decade. However, there is a lack of specific markers for characterizing the disease stages while considering this population's differential features. Methods: Forty-one DS individuals participated in the study, and were classified into three groups according to their clinical status: Alzheimer's disease (AD-DS), mild cognitive impairment (MCI-DS), and controls (CN-DS). We performed an exhaustive neuropsychological evaluation and assessed brain functional connectivity (FC) from magnetoencephalographic recordings. Results: Compared with CN-DS, both MCI-DS and AD-DS showed a pattern of increased FC within the high alpha band. The neuropsychological assessment showed a generalized cognitive impairment, especially affecting mnestic functions, in MCI-DS and, more pronouncedly, in AD-DS. Discussion: These findings might help to characterize the AD-continuum in DS. In addition, they support the role of the excitatory/inhibitory imbalance as a key pathophysiological factor in AD. Impact statement The pattern of functional connectivity (FC) hypersynchronization found in this study resembles the largely reported Alzheimer's disease (AD) FC evolution pattern in population with typical development. This study supports the hypothesis of the excitatory/inhibitory imbalance as a key pathophysiological factor in AD, and its conclusions could help in the characterization and prediction of Down syndrome individuals with a greater likelihood of converting to dementia.

S6K1 deficiency protects against apoptosis in hepatocytes.

UNLABELLED: The mammalian target of rapamycin (mTOR)/S6K1 signaling pathway controls cell growth and proliferation. To assess the importance of S6K1 in the balance between death and survival in the liver, we have generated immortalized hepatocyte cell lines from wild-type and S6K1-deficient (S6K1(-/-)) mice. In S6K1(-/-) hepatocytes, caspase-8 and the pro-apoptotic protein Bid were constitutively down-regulated as compared with wild-type. Moreover, S6K1(-/-) hepatocytes failed to respond to the apoptotic trigger of death receptor activation. Neither caspase-8 activation nor FLIP(L) degradation in response to tumor necrosis factor alpha (TNF-alpha) or anti-Fas antibody (Jo2) was observed in cells lacking S6K1. Downstream events such as Bid cleavage, cytochrome C release, caspase-3 activation, DNA laddering, as well as the percentage of apoptotic cells were attenuated as compared with wild-type. In addition, the anti-apoptotic protein Bclx(L) was down-regulated in TNF-alpha-treated or Jo2-treated wild-type hepatocytes, but this response was abolished in S6K1(-/-)cells. In vivo, S6K1-deficient mice were protected against concanavalin A-induced apoptosis. The withdrawal of growth factors strongly induced apoptosis in wild-type, but not in S6K1(-/-) hepatocytes. S6K1 deficiency did not decrease Bclx(L)/Bim ratio on serum withdrawal, thereby protecting cells from cytochrome C release and DNA fragmentation. At the molecular level, the lack of S6K1-mediated negative feedback decreased insulin receptor substrate-1 (IRS-1) serine phosphorylation, resulting in activation of survival pathways mediated by phosphatidylinositol 3-kinase/Akt and extracellular signal-regulated kinase (ERK). However, S6K1(-/-) hepatocytes underwent apoptosis on serum withdrawal in combination with phosphatidylinositol 3-kinase (PI3K) or ERK inhibitors. CONCLUSION: This finding might explain the mechanism of resistance to mTOR inhibitors in cancer treatments and strongly suggests that the inhibition of S6K1 could protect against acute liver failure and, in combination with inhibitors that abrogate the sustained activation of Akt and ERK, could improve the efficacy of hepatocarcinoma (HCC) treatment.

International research and just sharing of benefits in Mexico.

International research enrolling human subjects has raised an ethical concern regarding the just distribution of benefits between the countries that design the research and the host communities. Although several universal declarations have expressed this concern, a gap between theory and practice continues to exist, as well as a significant divergence between the design of the research protocol and the social context where it will be implemented. Although institutional review boards have made a valuable effort to evaluate international research, their sensitivity to the just sharing of research benefits as well as their attention to the social context must be evaluated. This article analyzes the distribution of benefits in a review of international research in Mexico and produces an ethical reflection based on the results.

Artificial neural networks as emulators of process-based models to analyse bathing water quality in estuaries.

This study aims to provide a method for developing artificial neural networks in estuaries as emulators of process-based models to analyse bathing water quality and its variability over time and space. The methodology forecasts the concentration of faecal indicator organisms, integrating the accuracy and reliability of field measurements, the spatial and temporal resolution of process-based modelling, and the decrease in computational costs by artificial neural networks whilst preserving the accuracy of results. Thus, the overall approach integrates a coupled hydrodynamic-bacteriological model previously calibrated with field data at the bathing sites into a low-order emulator by using artificial neural networks, which are trained by the process-based model outputs. The application of the method to the Eo Estuary, located on the northwestern coast of Spain, demonstrated that artificial neural networks are viable surrogates of highly nonlinear process-based models and highly variable forcings. The results showed that the process-based model and the neural networks conveniently reproduced the measurements of Escherichia coli (E. coli) concentrations, indicating a slightly better fit for the process-based model (R2 = 0.87) than for the neural networks (R2 = 0.83). This application also highlighted that during the model setup of both predictive tools, the computational time of the process-based approach was 0.78 times lower than that of the artificial neural networks (ANNs) approach due to the additional time spent on ANN development. Conversely, the computational costs of forecasting are considerably reduced by the neural networks compared with the process-based model, with a decrease in hours of 25, 600, 3900, and 31633 times for forecasting 1 h, 1 day, 1 month, and 1 bathing season, respectively. Therefore, the longer the forecasting period, the greater the reduction in computational time by artificial neural networks.

Neuropsychological and neurophysiological characterization of mild cognitive impairment and Alzheimer's disease in Down syndrome.

Down syndrome (DS) has been considered a unique model for the investigation of Alzheimer's disease (AD) but intermediate stages in the continuum are poorly defined. Considering this, we investigated the neurophysiological (i.e., magnetoencephalography [MEG]) and neuropsychological patterns of mild cognitive impairment (MCI) and AD in middle-aged adults with DS. The sample was composed of four groups: Control-DS (n = 14, mean age 44.64 ± 3.30 years), MCI-DS (n = 14, 51.64 ± 3.95 years), AD-DS (n = 13, 53.54 ± 6.58 years), and Control-no-DS (healthy controls, n = 14, 45.21 ± 4.39 years). DS individuals were studied with neuropsychological tests and MEG, whereas the Control-no-DS group completed only the MEG session. Our results showed that the AD-DS group exhibited a significantly poorer performance as compared with the Control-DS group in all tests. Furthermore, this effect was crucially evident in AD-DS individuals when compared with the MCI-DS group in verbal and working memory abilities. In the neurophysiological domain, the Control-DS group showed a widespread increase of theta activity when compared with the Control-no-DS group. With disease progression, this increased theta was substituted by an augmented delta, accompanied with a reduction of alpha activity. Such spectral pattern-specifically observed in occipital, posterior temporal, cuneus, and precuneus regions-correlated with the performance in cognitive tests. This is the first MEG study in the field incorporating both neuropsychological and neurophysiological information, and demonstrating that this combination of markers is sensitive enough to characterize different stages along the AD continuum in DS.

[Type 2 diabetes and depression in Guadalajara , Mexico , 2005]. / Diabetes Tipo 2 y Depresión en Guadalajara, México. 2005.

OBJECTIVE: Determining the prevalence of depression and comparing sociodemographic, metabolic and clinical indicators in depressed and non-depressed people suffering from type 2 diabetes. METHODS: A comparative cross-sectional study was carried out on a sample of 450 people aged over 30 suffering from type 2 diabetes; they had been diagnosed more than one year before and psychopathology had not been determined for them. A modified Zung's scale was applied and a sociodemographic survey carried out. Glucosylated haemoglobin, body mass index (BMI), blood pressure and glycemia in fasting were all evaluated. Diagnostic history and clinical state regarding diabetes were recorded. RESULTS: There was 63 % depression prevalence in a 3 to 1 ratio, this being greater in women than in men (2,08-4,82 95 %CI, p=0.00). Differences between depressed and non-depressed people were found in schooling, civil state and occupation (p<0.05); differences were not presented with age, just like metabolic variables, except for IMC, diagnostic history and clinical states 3 and 4. No association was found between socio-demographic and clinical metabolic variables by gender (p>0.05); however, diagnostic history and clinical state were associated with gender, the former being associated just with men and the latter with both sexes. CONCLUSIONS: The prevalence of depression was high in people suffering from diabetes and women were at greater risk. No association was revealed between age and people suffering from diabetes who were depressed, unlike schooling, civil state and occupation; depression was presented more amongst people having a longer diagnostic history of diabetes and greater BMI.

Merkel cell carcinoma of the head and neck: report of seven cases.

Merkel cell carcinoma is a rare and aggressive primary cutaneous neoplasm. Clinically it is characterized by innocuous appearance, as a fast growing asymptomatic nodule or plaque. Head and neck are the most common sites of presentation (50%). The treatment is based on local surgery completed with cervical lymph node dissection, radiotherapy, chemotherapy and other treatments depending on the staging. Sentinel lymph biopsy seems to be useful for its treatment. Tumour staging is the only prognostic factor related to overall survival. Prognosis is very poor due to the high incidence of loco-regional recurrence and metastases. Seven cases of Merkel cell carcinoma of the head and neck are reported. These were treated in our Department over the last two and a half years. A literature review was made.

Assessment of ecosystem services of an urbanized tropical estuary with a focus on habitats and scenarios.

Tropical estuaries are one of the most valuable ecosystems on the planet because of the number of ecosystem services they provide. The increasing anthropogenic pressure to which these estuaries are subject has caused a reduction in their natural capital stock. Therefore, the application of a pragmatic and rational ecosystem-based management approach to sustainably manage the multiple ecosystem services provided by this ecosystem is necessary. The aim of our study is to present an approach that combines prospective scenarios with habitat-based perspective to assess the supply capacity of ecosystem services, plus determine the impact of protected areas in an urbanized tropical estuary. The current situation and two scenarios were generated to evaluate the capacity of habitats to supply ecosystem services. This type of assessment will allow the decision makers to visualize the effect of their choices or the occurrence of events which might produce significant changes in the estuary. Thus, over time, measures can be taken to sustain the supply of ecosystem services. We determined that the establishment of protected areas have a positive impact; however, the effect is not the same for all of them. Consequently, indicating that actions such as community participation, research, education, management planning and infrastructure development must accompany the development of a protected area.

Translation and validation of the Spanish version of the Health of the Nation Outcome Scales for People with Learning Disabilities (HoNOS-LD). / Traducción y validación de la versión española de la escala Health of the Nation Outcome Scales for People with Learning Disabilities (HoNOS-LD).

INTRODUCTION: The Health of the Nation Outcome Scales for People with Learning Disabilities (HoNOS-LD) is a brief instrument that assesses functioning in people with intellectual development disorder and mental health problems/behaviour disorders. The aim of the present study was to examine the evidence on the validity of the scores based on the Spanish version of the HoNOS-LD. MATERIAL AND METHODS: The study included 111 participants that were assessed by the Spanish version of the HoNOS-LD and other questionnaires that measured different variables related to the scale. Thirty-three participants were assessed by 2 examiners, and retested 7 days later, in order to study inter-examiner reliability and test-retest reliabilities. RESULTS: Based on clinical and conceptual criteria, and on the results of the parallel analysis, a factorial solution with one factor was selected. Internal consistency was good (Omega coefficient of 0.87). Inter-examiner and test-retest reliabilities were excellent (intraclass correlation coefficients of 0.95 and 0.98, respectively). Correlations between sections of the HoNOS-LD and the related instruments showed the expected direction, and were highly significant (P<.001), and the HoNOS-LD score increased with the intensity of the support required by the participants. These results showed evidence of the validity of association with other external variables. CONCLUSIONS: The Spanish version of the HoNOS-LD is a brief, valid and reliable instrument, which will enable a routine assessment of functioning for different uses, including diagnosis and intervention.

A longitudinal study of brain anatomy changes preceding dementia in Down syndrome.

Background: We longitudinally assessed Down syndrome individuals at the age of risk of developing dementia to measure changes in brain anatomy and their relationship to cognitive impairment progression. Methods: Forty-two Down syndrome individuals were initially included, of whom 27 (mean age 46.8 years) were evaluable on the basis of completing the 2-year follow-up and success in obtaining good quality MRI exams. Voxel-based morphometry was used to estimate regional brain volumes at baseline and follow-up on 3D anatomical images. Longitudinal volume changes for the group and their relationship with change in general cognitive status and specific cognitive domains were mapped. Results: As a group, significant volume reduction was identified in the substantia innominata region of the basal forebrain, hippocampus, lateral temporal cortex and left arcuate fasciculus. Volume reduction in the substantia innominata and hippocampus was more prominent in individuals whose clinical status changed from cognitively stable to mild cognitive impairment or dementia during the follow-up. Relevantly, longitudinal memory score change was specifically associated with volume change in the hippocampus, prospective memory with prefrontal lobe and verbal comprehension with language-related brain areas. Conclusions: Results are notably concordant with the well-established anatomical changes signaling the progression to dementia in Alzheimer's disease, despite the dense baseline pathology that developmentally accumulates in Down syndrome. This commonality supports the potential value of Down syndrome as a genetic model of Alzheimer's neurodegeneration and may serve to further support the view that Down syndrome patients are best candidates to benefit from treatment research in Alzheimer's disease.

•Longitudinal changes in brain anatomy were identified in Down syndrome individuals.•Basal forebrain and hippocampal volume reductions paralleled clinical progression.•The overall anatomical pattern identified resembled Alzheimer's neurodegeneration.

Conocimientos del programa PrevenIMSS en usuarios de una unidad de medicina familiar / Knowledge of PrevenIMSS Programs in users of a primary health care clinic

Introducción: los programas PrevenIMSS son una estrategia para promover la salud en los tres niveles de prevención, con especial énfasis en el primer nivel de atención. Uno de sus objetivos es impactar en la morbimortalidad de enfermedades crónicas no transmisibles, como obesidad, diabetes e hipertensión, cuya prevención requiere de conocimientos para el autocuidado de la salud contenidos en estas guías. Objetivo: identificar la información que tienen los derechohabientes del IMSS sobre el autocuidado de la salud contenida en las guías PrevenIMSS. Material y métodos: estudio descriptivo transversal. Previa firma de consentimiento informado se entrevistó a mil derechohabientes de una unidad de medicina familiar; 200 por cada grupo etario PrevenIMSS. Se formularon preguntas acerca de: 1. Promoción de la salud, 2. Prevención y control de enfermedades, 3. Detección de enfermedades, 4. Nutrición, 5. Salud sexual y reproductiva, y una pregunta abierta para identificar sus necesidades sobre el autocuidado de la salud. Resultados: los encuestados respondieron tener conocimientos acerca de los componentes PrevenIMSS en: Promoción de la salud, el 62%; Nutrición, 43%; Prevención de enfermedades, 55.3%; Detección y control de enfermedades, 51.9%, y Salud sexual y reproductiva, 49.9%. El puntaje total obtenido por grupo etario fue: 0-9 años: 46.35 ± 14.36; 10-19 años: 46.02 ± 12.06; mujeres de 20 a 59 años: 46.79 ± 8.19, hombres de 20 a 59 años: 52.19 ±14.58, y adultos mayores de 60 años y más: 46.65 ± 13.34. Conclusiones: la menor información se tiene en nutrición. El grupo de adolescentes fue el más afectado.

Background: The PrevenIMSS programs are a strategy to promote health self-care at the three levels of prevention, with special emphasis on primary health care. One of its objectives is to have an impact on the morbidity and mortality of chronic non-communicable diseases such as obesity, diabetes and hypertension, the prevention of these illnesses requires knowledge for health self-care contained in these guidelines. Objective: To identify the information that the IMSS beneficiaries have on self-care of health contained in the PrevenIMSS guidelines. Material and methods: Descriptive cross-sectional study. After signing the informed consent, one thousand beneficiaries of a UMF were interviewed, 200 for each PrevenIMSS age group. Questions were asked about: 1. Health promotion, 2. Prevention and control of diseases, 3. Detection of diseases, 4. Nutrition, 5. Sexual and reproductive health, and an open question, to identify their needs for self-care of health. Results: The respondents answered having knowledge about the PrevenIMSS components in: Health promotion: 62%. Nutrition: 43%. Disease prevention: 55.3%. Detection and control of diseases: 51.9%. Sexual and reproductive health: 49.9%. The total score obtained by age group was: 0-9 years 46.35 ± 14.36; 10-19 years 46.02 ± 12.06; women from 20 to 59 years old 46.79 ± 8.19, men from 20 to 59 years old 52.19 ± 14.58; adults aged 60 and over 46.65 ± 13.34. Conclusions: The least information is in nutrition. The group of adolescents was the most affected.