Detalhe da pesquisa
1.
Structure-activity relationship and molecular modelling studies of quinazolinedione derivatives MMV665916 as potential antimalarial agent.
Bioorg Med Chem
; 51: 116513, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34798379
2.
Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation.
Bioorg Chem
; 98: 103750, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32182520
3.
Enzyme inhibitors for drug discovery.
Amino Acids
; 55(12): 1707-1708, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38017350
4.
Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases.
Molecules
; 23(10)2018 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30314342
5.
Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis.
Proteins
; 85(8): 1413-1421, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28383176
6.
Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo.
Malar J
; 16(1): 382, 2017 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28934959
7.
Exploring S1 plasticity and probing S1' subsite of mammalian aminopeptidase N/CD13 with highly potent and selective aminobenzosuberone inhibitors.
Bioorg Med Chem
; 23(13): 3192-207, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25982416
8.
Synthesis of amino-hydroxy-benzocycloheptenones as potent, selective, non-peptidic dinuclear zinc metalloaminopeptidase inhibitors.
Bioorg Med Chem
; 21(21): 6447-55, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24055078
9.
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.
J Med Chem
; 66(13): 8896-8916, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37343180
10.
Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors.
Bioorg Med Chem
; 20(16): 4942-53, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22796349
11.
Amino-benzosuberone: a novel warhead for selective inhibition of human aminopeptidase-N/CD13.
Bioorg Med Chem
; 19(4): 1434-49, 2011 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21292493
12.
Silver-catalysed Doyle-Kirmse reaction of allyl and propargyl sulfides.
Org Biomol Chem
; 7(7): 1276-9, 2009 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19300808
13.
Alkynes as masked ylides: gold-catalysed intermolecular reactions of propargylic carboxylates with sulfides.
Chem Commun (Camb)
; (2): 238-40, 2008 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18092099
14.
Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection.
Sci Rep
; 7: 46045, 2017 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28393915
15.
Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.
J Med Chem
; 58(19): 7695-706, 2015 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26418485
16.
Gold- or platinum-catalyzed synthesis of sulfur heterocycles: access to sulfur ylides without using sacrificial functionality.
Angew Chem Int Ed Engl
; 48(44): 8372-5, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19784994
17.
Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors.
Bioorg Med Chem
; 14(21): 7241-57, 2006 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16844380