Detalhe da pesquisa
1.
Coumarins-lipophilic cations conjugates: Efficient mitocans targeting carbonic anhydrases.
Bioorg Chem
; 145: 107168, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38354500
2.
Novel multifunctional tacrine-donepezil hybrids against Alzheimer's disease: Design synthesis and bioactivity studies.
Arch Pharm (Weinheim)
; : e2300575, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38593283
3.
Targeting SARS-CoV-2 Main Protease: A Successful Story Guided by an In Silico Drug Repurposing Approach.
J Chem Inf Model
; 63(11): 3601-3613, 2023 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37227780
4.
Design, synthesis, biological activity evaluation and structure-activity relationships of new steroidal aromatase inhibitors. The case of C-ring and 7ß substituted steroids.
Bioorg Chem
; 131: 106286, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36459778
5.
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity.
Bioorg Chem
; 140: 106794, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37659146
6.
2H-chromene and 7H-furo-chromene derivatives selectively inhibit tumour associated human carbonic anhydrase IX and XII isoforms.
J Enzyme Inhib Med Chem
; 38(1): 2270183, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37870190
7.
Hit identification of novel small molecules interfering with MALAT1 triplex by a structure-based virtual screening.
Arch Pharm (Weinheim)
; 356(8): e2300134, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37309243
8.
HSV-1 Glycoprotein D and Its Surface Receptors: Evaluation of Protein-Protein Interaction and Targeting by Triazole-Based Compounds through In Silico Approaches.
Int J Mol Sci
; 24(8)2023 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37108255
9.
Natural Agents as Novel Potential Source of Proteasome Inhibitors with Anti-Tumor Activity: Focus on Multiple Myeloma.
Molecules
; 28(3)2023 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36771100
10.
Exploiting DNA Ligase III addiction of multiple myeloma by flavonoid Rhamnetin.
J Transl Med
; 20(1): 482, 2022 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36273153
11.
ABCC Transporters Mediate the Vacuolar Accumulation of Crocins in Saffron Stigmas.
Plant Cell
; 31(11): 2789-2804, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31548254
12.
Evaluation of chromane derivatives: Promising privileged scaffolds for lead discovery within Alzheimer's disease.
Bioorg Med Chem
; 68: 116807, 2022 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35653868
13.
From Nature to Synthetic Compounds: Novel 1(N),2,3 Trisubstituted-5-oxopyrrolidines Targeting Multiple Myeloma Cells.
Int J Mol Sci
; 23(21)2022 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36361848
14.
The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma.
Int J Mol Sci
; 23(18)2022 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36142133
15.
Molecular Modeling and Experimental Evaluation of Non-Chiral Components of Bergamot Essential Oil with Inhibitory Activity against Human Monoamine Oxidases.
Molecules
; 27(8)2022 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35458667
16.
Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach.
Molecules
; 27(21)2022 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36364347
17.
Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control.
J Antimicrob Chemother
; 76(2): 396-412, 2021 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33254234
18.
Novel propargylamine-based inhibitors of cholinesterases and monoamine oxidases: Synthesis, biological evaluation and docking study.
Bioorg Chem
; 116: 105301, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34492558
19.
Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses.
Drug Resist Updat
; 53: 100721, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33132205
20.
Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives.
J Enzyme Inhib Med Chem
; 36(1): 685-692, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33602041