Pesquisa | Portal de Pesquisa da BVS

1.

Alsinol, an arylamino alcohol derivative active against Plasmodium, Babesia, Trypanosoma, and Leishmania: past and new outcomes.

Arias, Maria H; Quiliano, Miguel; Bourgeade-Delmas, Sandra; Fabing, Isabelle; Chantal, Isabelle; Berthier, David; Minet, Cécile; Eparvier, Veronique; Sorres, Jonathan; Stien, Didier; Galiano, Silvia; Aldana, Ignacio; Valentin, Alexis; Garavito, Giovanny; Deharo, Eric.

Parasitol Res ; 119(10): 3503-3515, 2020 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-32772176

2.

Primaquine-quinoxaline 1,4-di-N-oxide hybrids with action on the exo-erythrocytic forms of Plasmodium induce their effect by the production of reactive oxygen species.

Bonilla-Ramírez, Leonardo; Galiano, Silvia; Quiliano, Miguel; Aldana, Ignacio; Pabón, Adriana.

Malar J ; 18(1): 201, 2019 Jun 19.

Artigo em Inglês | MEDLINE | ID: mdl-31217011

3.

Pediatric asthma treatment: What to do when international guideline recommendations do not agree.

Larenas Linnemann, Désirée E S; Fernández Vega, Margarita; Luna Pech, Jorge Agustín; Villaverde Rosas, Jimena; Ortega Martell, José Antonio; Del Río Navarro, Blanca Estela; Cano Salas, María Del Carmen; Romero Lombard, Jade; López Estrada, Erika Del Carmen; Rodriguez-González, Monica; Mayorga Butrón, José Luis; Salas Hernández, Jorge; Vázquez García, Juan Carlos; Ortiz Aldana, Ignacio; Vargas Becerra, Mario Humberto; Bedolla Barajas, Martín; Rodríguez Pérez, Noel; Aguilar Aranda, Ambrocio; Jiménez González, Carlos Adrián; García Bolaños, Carlos; Garrido Galindo, Claudia; Mendoza Hernández, David Alejandro; Mendoza López, Enrique; López Pérez, Gerardo; Wakida Kuzonoki, Guillermo Hideo; Ruiz Gutiérrez, Héctor Hernán; León Molina, Héctor; Martínez de la Lanza, Héctor; Stone Aguilar, Héctor; Gómez Vera, Javier; Olvera Salinas, Jorge; Oyoqui Flores, José Joel; Gálvez Romero, José Luis; Lozano Saenz, José Santos; Salgado Gama, Juan Ignacio; Jiménez Chobillon, Marcos Alejandro; García Avilés, Martha Angélica; Guinto Balanzar, Martha Patricia; Medina Ávalos, Miguel Alejandro; Camargo Angeles, Robert; García Torrentera, Rogelio; Toral Freyre, Saraí; Montes Narvaez, Gabriel; Solorio Gómez, Héctor; Rosas Peña, Juan; Romero Tapia, Sergio Jesús; Reyes Herrera, Adela; Cuevas Schacht, Francisco; Esquer Flores, Joaquín; Sacre Hazouri, José Antonio.

Ann Allergy Asthma Immunol ; 121(1): 7-13.e4, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29551403

4.

New hydrazine and hydrazide quinoxaline 1,4-di-N-oxide derivatives: In silico ADMET, antiplasmodial and antileishmanial activity.

Quiliano, Miguel; Pabón, Adriana; Ramirez-Calderon, Gustavo; Barea, Carlos; Deharo, Eric; Galiano, Silvia; Aldana, Ignacio.

Bioorg Med Chem Lett ; 27(8): 1820-1825, 2017 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-28291694

5.

Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents.

Gil, Ana; Pabón, Adriana; Galiano, Silvia; Burguete, Asunción; Pérez-Silanes, Silvia; Deharo, Eric; Monge, Antonio; Aldana, Ignacio.

Molecules ; 19(2): 2166-80, 2014 Feb 18.

Artigo em Inglês | MEDLINE | ID: mdl-24552985

6.

New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities.

Barea, Carlos; Pabón, Adriana; Pérez-Silanes, Silvia; Galiano, Silvia; Gonzalez, German; Monge, Antonio; Deharo, Eric; Aldana, Ignacio.

Molecules ; 18(4): 4718-27, 2013 Apr 22.

Artigo em Inglês | MEDLINE | ID: mdl-23609622

7.

The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine.

Garavito, Giovanny; Bertani, Stéphane; Quiliano, Miguel; Valentin, Alexis; Aldana, Ignacio; Deharo, Eric.

Mem Inst Oswaldo Cruz ; 107(6): 820-3, 2012 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-22990975

8.

New quinoxaline derivatives as potential MT1 and MT2 receptor ligands.

Ancizu, Saioa; Castrillo, Nerea; Pérez-Silanes, Silvia; Aldana, Ignacio; Monge, Antonio; Delagrange, Philippe; Caignard, Daniel-Henry; Galiano, Silvia.

Molecules ; 17(7): 7737-57, 2012 Jun 25.

Artigo em Inglês | MEDLINE | ID: mdl-22732886

9.

Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.

Barea, Carlos; Pabón, Adriana; Galiano, Silvia; Pérez-Silanes, Silvia; Gonzalez, German; Deyssard, Chloe; Monge, Antonio; Deharo, Eric; Aldana, Ignacio.

Molecules ; 17(8): 9451-61, 2012 Aug 07.

Artigo em Inglês | MEDLINE | ID: mdl-22871647

10.

New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterium tuberculosis agents.

Torres, Enrique; Moreno, Elsa; Ancizu, Saioa; Barea, Carlos; Galiano, Silvia; Aldana, Ignacio; Monge, Antonio; Pérez-Silanes, Silvia.

Bioorg Med Chem Lett ; 21(12): 3699-703, 2011 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-21570839

11.

New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities.

Barea, Carlos; Pabón, Adriana; Castillo, Denis; Zimic, Mirko; Quiliano, Miguel; Galiano, Silvia; Pérez-Silanes, Silvia; Monge, Antonio; Deharo, Eric; Aldana, Ignacio.

Bioorg Med Chem Lett ; 21(15): 4498-502, 2011 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-21724395

12.

Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure-activity relationships.

Mendoza, Adela; Pérez-Silanes, Silvia; Quiliano, Miguel; Pabón, Adriana; Galiano, Silvia; González, Germán; Garavito, Giovanny; Zimic, Mirko; Vaisberg, Abraham; Aldana, Ignacio; Monge, Antonio; Deharo, Eric.

Exp Parasitol ; 128(2): 97-103, 2011 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-21354139

13.

Trypanocidal properties, structure-activity relationship and computational studies of quinoxaline 1,4-di-N-oxide derivatives.

Estevez, Yannick; Quiliano, Miguel; Burguete, Asunción; Cabanillas, Billy; Zimic, Mirko; Málaga, Edith; Verástegui, Manuela; Pérez-Silanes, Silvia; Aldana, Ignacio; Monge, Antonio; Castillo, Denis; Deharo, Eric.

Exp Parasitol ; 127(4): 745-51, 2011 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-21272583

14.

Studies on log Po/w of quinoxaline di-N-oxides: a comparison of RP-HPLC experimental and predictive approaches.

Moreno, Elsa; Gabano, Elisabetta; Torres, Enrique; Platts, James A; Ravera, Mauro; Aldana, Ignacio; Monge, Antonio; Pérez-Silanes, Silvia.

Molecules ; 16(9): 7893-908, 2011 Sep 13.

Artigo em Inglês | MEDLINE | ID: mdl-22143549

15.

New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents.

Ancizu, Saioa; Moreno, Elsa; Solano, Beatriz; Villar, Raquel; Burguete, Asunción; Torres, Enrique; Pérez-Silanes, Silvia; Aldana, Ignacio; Monge, Antonio.

Bioorg Med Chem ; 18(7): 2713-9, 2010 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-20233660

16.

Building a MCHR1 homology model provides insight into the receptor-antagonist contacts that are important for the development of new anti-obesity agents.

Cirauqui, Nuria; Schrey, Anna K; Galiano, Silvia; Ceras, Javier; Pérez-Silanes, Silvia; Aldana, Ignacio; Monge, Antonio; Kühne, Ronald.

Bioorg Med Chem ; 18(21): 7365-79, 2010 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-20932767

17.

Selective activity against Mycobacteriumtuberculosis of new quinoxaline 1,4-di-N-oxides.

Vicente, Esther; Pérez-Silanes, Silvia; Lima, Lidia M; Ancizu, Saioa; Burguete, Asunción; Solano, Beatriz; Villar, Raquel; Aldana, Ignacio; Monge, Antonio.

Bioorg Med Chem ; 17(1): 385-9, 2009 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-19058970

18.

Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates.

Romeiro, Nelilma C; Aguirre, Gabriela; Hernández, Paola; González, Mercedes; Cerecetto, Hugo; Aldana, Ignacio; Pérez-Silanes, Silvia; Monge, Antonio; Barreiro, Eliezer J; Lima, Lídia M.

Bioorg Med Chem ; 17(2): 641-52, 2009 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-19110434

19.

New 1-aryl-3-substituted propanol derivatives as antimalarial agents.

Pérez-Silanes, Silvia; Berrade, Luis; García-Sánchez, Rory N; Mendoza, Adela; Galiano, Silvia; Pérez-Solórzano, Berta Martín; Nogal-Ruiz, Juan J; Martínez-Fernández, Antonio R; Aldana, Ignacio; Monge, Antonio.

Molecules ; 14(10): 4120-35, 2009 Oct 14.

Artigo em Inglês | MEDLINE | ID: mdl-19924051

20.

Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs.

Ancizu, Saioa; Moreno, Elsa; Torres, Enrique; Burguete, Asunción; Pérez-Silanes, Silvia; Benítez, Diego; Villar, Raquel; Solano, Beatriz; Marín, Adoración; Aldana, Ignacio; Cerecetto, Hugo; González, Mercedes; Monge, Antonio.

Molecules ; 14(6): 2256-72, 2009 Jun 22.

Artigo em Inglês | MEDLINE | ID: mdl-19553897

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