Detalhe da pesquisa
1.
Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450.
Chem Biol
; 3(4): 301-14, 1996 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-8807858
2.
Design, synthesis, and evaluation of tetrahydropyrimidinones as an example of a general approach to nonpeptide HIV protease inhibitors.
J Med Chem
; 40(11): 1707-9, 1997 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-9171880
3.
Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.
J Med Chem
; 34(8): 2525-47, 1991 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-1875348
4.
Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies.
J Med Chem
; 42(5): 819-32, 1999 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-10072680
5.
Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines.
J Med Chem
; 42(5): 833-48, 1999 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-10072681
6.
Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.
J Med Chem
; 39(18): 3514-25, 1996 Aug 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-8784449
7.
Antiviral agents. 2. Structure-activity relationships of compounds related to 1-adamantanamine.
J Med Chem
; 14(6): 535-43, 1971 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-5091970
8.
[3H]DUP 753, a highly potent and specific radioligand for the angiotensin II-1 receptor subtype.
Biochem Biophys Res Commun
; 172(3): 1195-202, 1990 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-2244903
9.
DMP 323, a nonpeptide cyclic urea inhibitor of human immunodeficiency virus (HIV) protease, specifically and persistently blocks intracellular processing of HIV gag polyprotein.
Antimicrob Agents Chemother
; 38(7): 1635-40, 1994 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-7979297
10.
Pharmacology of 2-amino-1,4-dihydro-4-(2-[4-[4-(2-methoxyphenyl)-1- piperazinyl]butylsulfinyl]phenyl)-6-methyl-5-nitro-3-pyridine carboxylic acid methyl ester (XB513), a novel calcium agonist with alpha-1 adrenergic receptor antagonistic.
J Pharmacol Exp Ther
; 265(3): 1088-95, 1993 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-8099616
11.
Total synthesis of yohimbine.
J Am Chem Soc
; 91(26): 7315-33, 1969 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-5358617