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1.
Bull Environ Contam Toxicol ; 93(3): 370-4, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25063371

RESUMO

This paper presents measurements of cesium 137 ((137)Cs) in the Syrian environment during the period between 2006 and 2010. More than 1,000 samples of soil, water, plants and aquatic life were collected from different locations. The measurements were realized using gamma spectroscopy, and the results showed that radioactivity concentrations were low overall. Concentrations ranged from below detection limits to several tens Bq kg(-1) (dry matter) or 9.8 mBq L(-1) (water), which were well below maximum allowable levels in food or drinking water as established according to Syrian national standards or the WHO/FAO Codex guidelines. However, high (137)Cs activity levels were observed in soil samples collected at a high elevation (Kadmous highs), where a mean concentration of 1,900 Bq kg(-1) was obtained.


Assuntos
Radioisótopos de Césio/análise , Poluentes Radioativos do Solo/análise , Poluentes Radioativos da Água/análise , Produtos Agrícolas/química , Monitoramento Ambiental , Água Doce/química , Poaceae/química , Solo/química , Síria
2.
Eur J Pharm Biopharm ; 112: 164-176, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27889415

RESUMO

Although bacterial nanocellulose (BNC) has been widely investigated in the last 10years as drug delivery system, up to now no long-term controlled release of drugs could be realized. Therefore, the aim of the present work was the development of a BNC-based drug delivery system that provides prolonged retention time for the antiseptic octenidine up to one week with improved mechanical and antimicrobial properties as well as a high biocompatibility. BNC was modified by incorporation of differently concentrated Poloxamers 338 and 407 as micelles and gels that were extensively investigated regarding size, surface charge, and dynamic viscosity. Depending on type and concentration of the Poloxamer, a retarded octenidine release up to one week could be accomplished. Additionally, superior material properties such as high compression stability and water binding could be achieved. The antimicrobial activity of octenidine against Staphylococcus aureus and Pseudomonas aeruginosa was not changed by the use of Poloxamers. Excellent biocompatibility of the Poloxamer loaded BNC could be demonstrated after local administration in a shell-less hen's egg model. In conclusion, a long-term delivery system consisting of BNC and Poloxamer could be developed for octenidine as a ready-to-use system e.g. for long-term dermal wound treatment.


Assuntos
Celulose/química , Portadores de Fármacos , Nanopartículas , Poloxâmero/química , Proteobactérias/química , Piridinas/administração & dosagem , Preparações de Ação Retardada , Iminas , Testes de Sensibilidade Microbiana , Pseudomonas aeruginosa/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacos
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