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J Chromatogr A ; 1294: 25-32, 2013 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-23647612

RESUMO

Phthalates, which are ubiquitous in the environment, are readily metabolized in human bodies to their respective monoesters. These phthalate monoesters are non-persistent with short half-lives, which make them the ideal biomarkers of human exposure to phthalates. In this study a direct analysis method without preconcentration was developed and validated for the following phthalate ester metabolites in urine: mono-(2-ethylhexyl) phthalate, mono-(2-ethyl-5-hydroxyhexyl) phthalate, mono-(2-ethyl-5-oxohexyl)phthalate, monobenzyl phthalate, mono-isobutylphthalate, mono-n-butyl phthalate and monoethyl phthalate. The recovery of the phthalate ester metabolites varied between 97% and 104%. The intraday precision for the replicate analysis (n=10) of a urine sample did not exceed 5% for most of the compounds. The coefficient of variance amounted to 2-3%. The limit of quantification was set equal to 0.5µg/L for the majority of the compounds. A comparison between the direct analysis method and a foregoing solid phase extraction (SPE) of the urine sample was made. Finally, the applicability of the direct analysis method was tested in three interlaboratory comparisons.


Assuntos
Poluentes Ambientais/isolamento & purificação , Poluentes Ambientais/urina , Ácidos Ftálicos/isolamento & purificação , Ácidos Ftálicos/urina , Extração em Fase Sólida/métodos , Biomarcadores/urina , Exposição Ambiental , Poluentes Ambientais/metabolismo , Humanos , Ácidos Ftálicos/metabolismo
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