Detalhe da pesquisa
1.
Direct-to-biology platform: From synthesis to biological evaluation of SHP2 allosteric inhibitors.
Bioorg Med Chem Lett
; 100: 129626, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38266789
2.
Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature
; 550(7677): 481-486, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29045389
3.
Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors.
ACS Med Chem Lett
; 14(5): 645-651, 2023 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37197453
4.
Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors.
ACS Med Chem Lett
; 14(2): 156-162, 2023 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36793438
5.
Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes.
Commun Biol
; 5(1): 547, 2022 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35668202
6.
Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity.
Bioorg Med Chem
; 18(19): 7113-20, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20817473
7.
Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.
PLoS Negl Trop Dis
; 14(5): e0008339, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32437349
8.
PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer.
Mol Cancer Ther
; 6(12 Pt 1): 3158-68, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18089710
9.
Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1.
J Med Chem
; 60(19): 7984-7999, 2017 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28892629
10.
NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies.
Mol Cancer Ther
; 11(4): 1006-16, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22319201
11.
Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.
J Med Chem
; 53(20): 7296-315, 2010 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20873740