1.
J Neuroimmunol
; 226(1-2): 192-3, 2010 Sep 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20655601
RESUMO
B cells isolated from the CSF of patients with multiple sclerosis (MS) have a unique accumulation of somatic hypermutation within the B cell receptor, termed the antibody gene signature (AGS). The focus of this study was to investigate whether the AGS could also be detected in MS brain tissue. Genetic analysis of B cells isolated from post-mortem CNS tissue samples from four MS brains demonstrated that signature enriched B cells are present at the site of tissue injury as well as in the circulating CSF.