Detalhe da pesquisa
1.
Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.
J Pharmacol Exp Ther
; 386(2): 242-258, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37308266
2.
Biochemical Properties of TAK-828F, a Potent and Selective Retinoid-Related Orphan Receptor Gamma t Inverse Agonist.
Pharmacology
; 102(5-6): 244-252, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30134246
3.
JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Sci Rep
; 13(1): 13524, 2023 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37598239
4.
Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology studies.
Placenta
; 125: 10-19, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35428514
5.
Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.
J Med Chem
; 65(21): 14721-14739, 2022 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36279149
6.
New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase.
ACS Med Chem Lett
; 11(8): 1645-1652, 2020 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34345355
7.
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
J Med Chem
; 63(6): 3215-3226, 2020 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32142284
8.
Cholesterol Unbound RORγt Protein Enables a Sensitive Inverse Agonist Screening.
Assay Drug Dev Technol
; 16(4): 194-204, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29874096
9.
Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Sci Rep
; 13(1): 20081, 2023 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37973811
10.
DDX1 is an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication.
J Mol Biol
; 415(1): 61-74, 2012 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22051512