Detalhe da pesquisa
1.
A phase I study of the antibody drug conjugate ASG-5ME, an SLC44A4-targeting antibody carrying auristatin E, in metastatic castration-resistant prostate cancer.
Invest New Drugs
; 37(5): 1052-1060, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30725389
2.
Metabolism of an Oxime-Linked Antibody Drug Conjugate, AGS62P1, and Characterization of Its Identified Metabolite.
Mol Pharm
; 15(6): 2384-2390, 2018 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29757653
3.
HPN328, a Trispecific T Cell-activating Protein Construct Targeting DLL3-Expressing Solid Tumors.
Mol Cancer Ther
; 2024 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38670552
4.
Safety and Efficacy of Engineered Toxin Body MT-3724 in Relapsed or Refractory B-cell Non-Hodgkin's Lymphomas and Diffuse Large B-cell Lymphoma.
Cancer Res Commun
; 2(5): 307-315, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36875713
5.
Phase I Trials of Anti-ENPP3 Antibody-Drug Conjugates in Advanced Refractory Renal Cell Carcinomas.
Clin Cancer Res
; 24(18): 4399-4406, 2018 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29848572
6.
Enfortumab Vedotin Antibody-Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models.
Cancer Res
; 76(10): 3003-13, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27013195
7.
Role of efflux pumps and metabolising enzymes in drug delivery.
Expert Opin Drug Deliv
; 2(4): 683-705, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16296794
8.
In vivo antiviral efficacy of a dipeptide acyclovir prodrug, val-val-acyclovir, against HSV-1 epithelial and stromal keratitis in the rabbit eye model.
Invest Ophthalmol Vis Sci
; 44(6): 2529-34, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12766053
9.
Molecular evidence and functional expression of P-glycoprotein (MDR1) in human and rabbit cornea and corneal epithelial cell lines.
Invest Ophthalmol Vis Sci
; 44(7): 2909-18, 2003 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12824231
10.
Current prodrug strategies via membrane transporters/receptors.
Expert Opin Biol Ther
; 2(6): 607-20, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12171505
11.
Transporters/receptors in the anterior chamber: pathways to explore ocular drug delivery strategies.
Expert Opin Biol Ther
; 3(1): 23-44, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12718729
12.
Effect of mono- and di-acylation on the ocular disposition of ganciclovir: physicochemical properties, ocular bioreversion, and antiviral activity of short chain ester prodrugs.
J Pharm Sci
; 91(3): 660-8, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11920751
13.
Validation of an ocular microdialysis technique in rabbits with permanently implanted vitreous probes: systemic and intravitreal pharmacokinetics of fluorescein.
Int J Pharm
; 281(1-2): 79-88, 2004 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15288345
14.
Novel dipeptide prodrugs of acyclovir for ocular herpes infections: Bioreversion, antiviral activity and transport across rabbit cornea.
Curr Eye Res
; 26(3-4): 151-63, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12815543
15.
Amino acid prodrugs of acyclovir as possible antiviral agents against ocular HSV-1 infections: interactions with the neutral and cationic amino acid transporter on the corneal epithelium.
Curr Eye Res
; 29(2-3): 153-66, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15512962
16.
In vitro and in vivo evaluation of cysteine and site specific conjugated herceptin antibody-drug conjugates.
PLoS One
; 9(1): e83865, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24454709
17.
The assay design used for measurement of therapeutic antibody concentrations can affect pharmacokinetic parameters: Case studies.
MAbs
; 4(5): 623-31, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22820463
18.
Developmental immunotoxicology assessment of rituximab in cynomolgus monkeys.
Toxicol Sci
; 119(1): 116-25, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20937725
19.
In vivo ocular pharmacokinetics of acyclovir dipeptide ester prodrugs by microdialysis in rabbits.
Mol Pharm
; 3(4): 431-40, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16889437
20.
Pharmacokinetics/pharmacodynamics of nondepleting anti-CD4 monoclonal antibody (TRX1) in healthy human volunteers.
Pharm Res
; 23(1): 95-103, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16308668